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凝血酶受体激动剂肽-14

凝血酶受体激动剂肽-14用途

SFLLRNPNDKYEPF是人工合成的thrombin受体激动剂肽段。

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凝血酶受体激动剂肽-14名称

[ CAS 号 ]:
137339-65-2

[ 中文名 ]:
凝血酶受体兴奋剂

[ 英文名 ]:
TRAP-14 trifluoroacetate salt

[中文别名 ]:

凝血酶受体激动剂肽-14

[英文别名 ]:

MFCD00133815
Thrombin Receptor Activator
TRAP
Thrombin Receptor Agonist Peptide
Thrombin Receptor Activator Peptide
Thrombin receptor agonist peptide-14
TRAP-14

凝血酶受体激动剂肽-14生物活性

[ 描述 ]:

SFLLRNPNDKYEPF是人工合成的thrombin受体激动剂肽段。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 凝血酶

研究领域 >> 心血管疾病

[体外研究]

凝血酶在精氨酸-41处切割其受体,导致产生具有序列SFLLRNPNDKYEPF的新受体NH2-末端。这种肽(TRP-14)可能发出各种凝血酶反应的信号[1]。发现SFLLRNPNDKYEPF,代表以人凝血酶受体的Ser-42开始的14个氨基酸,模拟凝血酶对血小板的作用。通过凝血酶切割人血小板凝血酶受体暴露出新的N-末端,其起到推定的束缚配体的作用。对应于新的N-末端区域的SFLLRNPNDKYEPF激活并诱导血小板聚集和血清素分泌。 SFLLRNPNDKYEPF是最小的肽长度,其在诱导[14C]血清素分泌中保持完全活性[2]。 TRAP诱导HUVECs的快速形态学改变,前列环素,内皮素,血小板活化因子,组织型纤溶酶原激活物和纤溶酶原激活物抑制剂-1的释放显着增加。用TRAP孵育细胞也会诱导细胞表面血栓调节蛋白的快速减少[3]。

[参考文献]

[1]. Sugama Y, et al. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism. Circ Res. 1992 Oct;71(4):1015-9.

[2]. Sabo T, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10.

[3]. Maruyama Y, et al. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9.

[相关活性小分子]

凝血酶受体激动剂肽-14物理化学性质

[ 分子式 ]:
C₈₁H₁₁₈N₂₀O₂₃

[ 分子量 ]:
1739.92000

[ 精确质量 ]:
1738.87000

[ PSA ]:
713.20000

[ LogP ]:
2.88170

[ 储存条件 ]:
−20°C

凝血酶受体激动剂肽-14MSDS

详细MSDS(安全技术说明书)

凝血酶受体激动剂肽-14安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
61

[ 安全声明 (欧洲) ]:
53-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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