< 生产厂家价格 >

单宁酸

单宁酸用途

Tannic acid 是一种新型的 hERG 通道阻塞剂,其IC50 值为 3.4 μM。

点击显示

单宁酸名称

[ CAS 号 ]:
1401-55-4

[ 中文名 ]:
单宁酸

[ 英文名 ]:
Tannic acid

[中文别名 ]:

[英文别名 ]:

Tannic acid
Gallotannin,Tannin
MFCD00066397
EINECS 215-753-2
Gallotannin Tannin
Glycerite

单宁酸生物活性

[ 描述 ]:

Tannic acid 是一种新型的 hERG 通道阻塞剂,其IC50 值为 3.4 μM。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钾通道

天然产物 >> 酚类

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[ 靶点 ]

IC50: 3.4 μM (hERG channel)[1]

[体内研究]

在治疗过程中,单宁酸显着改善AD皮肤病变中的这些表型。与AD小鼠相比,单宁酸处理降低了这些皮肤变化。单宁酸治疗增加AD皮肤切片中的PPARγ表达。在载体处理的AD小鼠中PPARγ蛋白表达受到抑制,但当用单宁酸处理时,其表达显着增加。在载体处理的AD小鼠中IL-1β,TNFα,TNFR1和COX2蛋白表达显着上调,但是通过单宁酸处理显着抑制IL-1β,TNFα,TNFR1和COX2蛋白表达[2]。

[动物实验]

使用无特定病原体的雌性6周龄小鼠。将动物保持在受控室内（温度23±2℃，湿度55±15％，光周期12小时）。 1周后，将小鼠分成3组，未处理组接受载体（蒸馏水）（正常，n = 5）;将DfE乳膏处理的小鼠（100mg /小鼠）分成两组，每组接受载体（蒸馏水）（AD，n = 5）或单宁酸（80mg / kg /天，每次口服）（AD +单宁酸， n = 5）并允许自由饮用水和标准实验室饮食[2]。

[参考文献]

[1]. Xi Chu, et al. Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PLoS One. 2015; 10(12): e0143797.

[2]. Karuppagounder V, et al. Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Dec;76(2):206-13.

[相关活性小分子]

单宁酸物理化学性质

[ 密度 ]:
2.1±0.1 g/cm3

[ 熔点 ]:
218 °C(lit.)

[ 分子式 ]:
C₇₆H₅₂O₄₆

[ 分子量 ]:
1701.198

[ 闪点 ]:
198°C

[ 精确质量 ]:
1700.172974

[ PSA ]:
777.98000

[ LogP ]:
13.33

[ 外观性状 ]:
淡黄色至黄褐色的固体带有一种微弱气味

[ 折射率 ]:
1.927

[ 储存条件 ]:
库房低温通风干燥

[ 稳定性 ]:
Stable. Incompatible with metallic salts, strong oxidizing agents, iron and other heavy metals.

[ 水溶解性 ]:
250 g/L (20 ºC)

单宁酸MSDS

详细MSDS(安全技术说明书)

单宁酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WU7185000

CHEMICAL NAME :: Sweet gum

CAS REGISTRY NUMBER :: 1401-55-4

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg/56W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 57,207,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1577 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 62 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82010 No. of Facilities: 2362 (estimated) No. of Industries: 41 No. of Occupations: 51 No. of Employees: 22302 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1577 No. of Facilities: 1650 (estimated) No. of Industries: 19 No. of Occupations: 29 No. of Employees: 41974 (estimated) No. of Female Employees: 19715 (estimated)

点击显示

单宁酸安全信息

[ 危害声明 ]:
H412

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
24/25-36-26-36/37/39-22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WW5075000

[ 海关编码 ]:
3201909000

单宁酸制备

1.将精萘100 kg投入磺化釜中，升温至125℃，在搅拌下加入浓硫酸120kg，在155～165℃下反应6～8h。取样测终点，如果完全溶于水则证明磺化完全。逐渐降温至110℃，加少量水稀释。在80℃左右将料液压入缩合釜。在70℃左右滴加37%的甲醛水溶液39kg，滴毕后在80～90℃下反应3h，得青黑色粘稠液即为成品。

制取方法：

2.五倍子粉碎后加4倍量热水于40～50℃温浸24h。滤出浸出液，加水冷却至5～8℃，加活性炭脱色过滤，滤液经过强酸性阴离子交换树脂除去无机盐。洗脱液浓缩后趁热倾入90%～95%乙醇，冷后过滤，滤液浓缩至干即为鞣酸成品。

点击显示

单宁酸海关

[ 海关编码 ]: 3201909000

单宁酸文献

Brief reports: Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes.

Stem Cells 33(1) , 301-9, (2014)

Despite controversies on the potential of hematopoietic stem cells (HSCs) to promote tissue repair, we previously showed that HSC transplantation could correct cystinosis, a multisystemic lysosomal st...

Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico.

BMC Complement Altern. Med. 15 , 244, (2015)

The increasing numbers of people who use plant-based remedies as alternative or complementary medicine call for the validation of less known herbal formulations used to treat their ailments. Since Pue...

Low molecular weight procyanidins from grape seeds enhance the impact of 5-Fluorouracil chemotherapy on Caco-2 human colon cancer cells.

PLoS ONE 9(6) , e98921, (2014)

Grape seed procyanidins (PC) are flavan-3-ol oligomers and polymers known for their biological activity in the gut. Grape seed extract (GSE) have been reported to reduce intestinal injury in a rat mod...

更多文献

单宁酸

单宁酸用途

单宁酸名称

单宁酸生物活性

单宁酸物理化学性质

单宁酸MSDS

详细MSDS(安全技术说明书)

单宁酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

单宁酸安全信息

单宁酸制备

单宁酸海关

单宁酸文献

相关化工产品/化学物质：

相关药品：

推荐生产厂家/供应商：

相关化合物