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3-甲基吡唑

3-甲基吡唑用途

3-Methylpyrazole 可作为硝化抑制剂用于土壤消化[1]。

3-甲基吡唑名称

[ CAS 号 ]:
1453-58-3

[ 中文名 ]:
3-甲基吡唑

[ 英文名 ]:
3-Methylpyrazole

[中文别名 ]:

3-甲基-1H-吡唑

[英文别名 ]:

3-Methyl-1H-pyrazole
EINECS 215-925-7
3-methyl-pyrazole
methyl pyrazol-
1H-Pyrazole, 3-methyl-
5-Methylpyrazole
3-Methyl-1,2-diazole
3-Methylpyrazole
Pyrazole,5-methyl
Pyrazole,3-methyl

3-甲基吡唑生物活性

[ 描述 ]:

3-Methylpyrazole 可作为硝化抑制剂用于土壤消化[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体外研究]

3-甲基吡唑可抑制大鼠肝微粒体对MAM的代谢[2]。

[参考文献]

[1]. G.W. McCarty, et al. Inhibition of nitrification in soil by heterocyclic nitrogen compounds. Biol Fertil Soils (1989) 8:204-211.

[2]. Fiala ES, et al. Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo. J Cancer Res Clin Oncol. 1987;113(2):145-50.

[相关活性小分子]

3-甲基吡唑物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
204.0±0.0 °C at 760 mmHg

[ 熔点 ]:
36 - 37ºC

[ 分子式 ]:
C₄H₆N₂

[ 分子量 ]:
82.104

[ 闪点 ]:
87.4±11.7 °C

[ 精确质量 ]:
82.053101

[ PSA ]:
28.68000

[ LogP ]:
0.78

[ 外观性状 ]:
淡黄色液体

[ 蒸汽压 ]:
0.4±0.3 mmHg at 25°C

[ 折射率 ]:
1.523

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
miscible

3-甲基吡唑MSDS

详细MSDS(安全技术说明书)

3-甲基吡唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ7340000

CHEMICAL NAME :: Pyrazole, 3-methyl-

CAS REGISTRY NUMBER :: 1453-58-3

BEILSTEIN REFERENCE NO. :: 0001454

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H6-N2

MOLECULAR WEIGHT :: 82.12

WISWESSER LINE NOTATION :: T5MNJ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Cardiac - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(9),50,1988

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 719 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(9),50,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement Behavioral - ataxia

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(6),29,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,27,1962

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3-甲基吡唑安全信息

[ 符号 ]:

GHS05, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H361

[ 警示性声明 ]:
P201-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
2810

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ7340000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29331990

3-甲基吡唑合成路线

详细合成路线

3-甲基吡唑上下游产品

3-甲基吡唑上游产品

3-甲基吡唑下游产品

3-甲基吡唑海关

[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-甲基吡唑文献

[Toxicological evaluation of a new nitrification inhibitor and its metabolite].

Gig. Sanit. (6) , 29-31, (1986)

Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo.

J. Cancer Res. Clin. Oncol. 113(2) , 145-50, (1987)

Using a hybrid ion-exchange reverse phase HPLC system, we found that F344 rat liver microsomes, in the presence of an NADPH-generating system, can metabolize methylazoxymethanol (MAM), a colon and liv...

Extremely long protection by pyrazole derivatives against chemically induced gastric mucosal injury.

J. Pharmacol. Exp. Ther. 256(2) , 592-8, (1991)

We tested the hypothesis that the gastrotoxicity of ethanol and other damaging agents is influenced through the modulation of alcohol dehydrogenase (ADH) by using either the ADH-inhibitor pyrazole or ...

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