邻香草醛

邻香草醛用途

邻香草醛(2-Vanillin)是一种天然产物,可从香草醛、红松果实中提取。邻香兰素是一种有效的抗真菌剂。邻香草醛通过破坏细胞壁和细胞膜的完整性来抑制菌丝体的生长。邻香草醛抑制阿霉素(HY-15142A)和4-过氧化氢环磷酰胺诱导的NF-κB活化[1][2]。

点击显示

邻香草醛名称

[ CAS 号 ]:
148-53-8

[ 中文名 ]:
邻香草醛

[ 英文名 ]:
3-Methoxysalicylaldehyde

[中文别名 ]:

[英文别名 ]:

2-Hydroxy-3-(methyloxy)benzaldehyde
ORTHO-VANILLIN
VHR BQ CO1
Benzaldehyde, 2-hydroxy-3-methoxy-
2-Hydroxy-m-anisaldehyde
EINECS 205-715-3
o-Vanillin
3-Methoxysalicylaldehyde
MFCD00003322
2-Hydroxy-3-methoxybenzaldehyde

邻香草醛生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[体外研究]

邻香草醛(2-香草醛；0-125μg/mL；24-72小时)以剂量依赖的方式抑制黄曲霉的菌丝生长[1]。邻香草醛(0-100μg/mL；48小时；黄曲霉)会改变菌丝体的形态,并导致菌丝体不规则收缩[1]。邻香草醛(0-100μg/mL；黄曲霉)可降低细胞壁表面的蛋白质含量和β-1,3-葡聚糖的含量[1]。邻香草醛(0-100μg/mL；黄曲霉)破坏细胞膜完整性。邻香草醛释放细胞成分并降低细胞外pH值[1]。邻香草醛(0-100μg/mL)可有效抑制玉米粒上黄曲霉的生长[1]。邻香草醛(0-250μ。邻香草醛将4-HC诱导的活性抑制43%[2]。

[体内研究]

邻香草醛(2-香草醛；60 mg/kg；口服；每天,持续5天)抑制携带A375人黑色素瘤异种移植物的小鼠的肿瘤生长[2]。动物模型：带有A375人黑色素瘤异种移植物的雄性NSG小鼠(12-16周龄)[2]剂量：60 mg/kg给药：口服给药；结果：在免疫缺陷NSG小鼠中,A375人黑色素瘤异种移植物的生长延迟。

邻香草醛物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
265.5±0.0 °C at 760 mmHg

[ 熔点 ]:
40-42 °C(lit.)

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
94.0±15.3 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
46.53000

[ LogP ]:
1.40

[ 外观性状 ]:
纤维状的,淡黄色,结晶固体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
slightly soluble

邻香草醛MSDS

详细MSDS(安全技术说明书)

邻香草醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU6530000

CHEMICAL NAME :: Benzaldehyde, 2-hydroxy-3-methoxy-

CAS REGISTRY NUMBER :: 148-53-8

BEILSTEIN REFERENCE NO. :: 0471913

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: VHR BQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,563,1982

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 347 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 243,609,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJANDP International Journal of Andrology. (Scriptor Publisher ApS, 15 Gasvaerksvej, DK-1656 Copenhagen V, Denmark) V.1- 1978- Volume(issue)/page/year: 10,741,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 238,2576,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 238,2576,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 238,2576,1954

点击显示

邻香草醛安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S23-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CU6530000

[ 海关编码 ]:
29124900

邻香草醛合成路线

详细合成路线

邻香草醛上下游产品

邻香草醛上游产品

邻香草醛下游产品

邻香草醛制备

1. 烟草：BU，56；FC，9， 18；BU，9.，18；合成：由异丁香酚经氧化制得，也可分别以黄樟油素、木质素、愈创木酚等位原料制得。

点击显示

邻香草醛海关

[ 海关编码 ]: 2912499000

[ 中文概述 ]:
2912499000. 其他醛醚、醛酚及含其他含氧基的醛. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

邻香草醛文献

3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.

Bioorg. Med. Chem. 15 , 2006-15, (2007)

Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-q...

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

Design, synthesis and characterization of novel binary V(V)-Schiff base materials linked with insulin-mimetic vanadium-induced differentiation of 3T3-L1 fibroblasts to adipocytes. Structure-function correlations at the molecular level.

J. Inorg. Biochem. 147 , 99-115, (2015)

Among the various roles of vanadium in the regulation of intracellular signaling, energy metabolism and insulin mimesis, its exogenous activity stands as a contemporary challenge currently under inves...

更多文献

邻香草醛

邻香草醛用途

邻香草醛名称

邻香草醛生物活性

邻香草醛物理化学性质

邻香草醛MSDS

详细MSDS(安全技术说明书)

邻香草醛毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

邻香草醛安全信息

邻香草醛合成路线

详细合成路线

邻香草醛上下游产品

邻香草醛上游产品

邻香草醛下游产品

邻香草醛制备

邻香草醛海关

邻香草醛文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物