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盐酸金刚乙胺

盐酸金刚乙胺用途

【用途1】
抗病毒药。通过抑制病毒颗粒在宿主细胞内脱壳而在病毒复制周期的早期起作用。用于预防A型流感病毒株引起的感染。
【用途2】
抗病毒药，用于A型流感病毒株引起的感染

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盐酸金刚乙胺名称

[ CAS 号 ]:
1501-84-4

[ 中文名 ]:
1-(1-金刚烷基)乙基胺盐酸盐

[ 英文名 ]:
Rimantadine Hydrochloride

[中文别名 ]:

[英文别名 ]:

1-(1-Adamantyl)ethylamine Hydrochloride
1-(Adamantan-1-yl)ethanamine hydrochloride (1:1)
Roflual
Meradan
α-Methyl-1-adamantanemethylamine hydrochloride
MFCD00072023
UNII:JEI07OOS8Y
a-Methyl-1-adamantanemethylamine Hydrochloride
1-(Adamantan-1-yl)ethanamine hydrochloride
1-Tricyclo[3.3.1.1]dec-1-ylethanaminhydrochlorid

盐酸金刚乙胺生物活性

[ 描述 ]:

Rimantadine(Flumadine)盐酸盐是口服抗流感病毒A化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 感染

[参考文献]

[1]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82.

[2]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78.

[相关活性小分子]

盐酸金刚乙胺物理化学性质

[ 沸点 ]:
247.8ºC at 760mmHg

[ 熔点 ]:
300ºC

[ 分子式 ]:
C₁₂H₂₂ClN

[ 分子量 ]:
215.763

[ 闪点 ]:
99.3ºC

[ 精确质量 ]:
215.144073

[ PSA ]:
26.02000

[ LogP ]:
4.05230

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0251mmHg at 25°C

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
Freely soluble in water.

盐酸金刚乙胺MSDS

盐酸金刚乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU4717000

CHEMICAL NAME :: 1-Adamantanemethylamine, alpha-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 1501-84-4

LAST UPDATED :: 199803

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H21-N.Cl-H

MOLECULAR WEIGHT :: 215.80

WISWESSER LINE NOTATION :: L66 B6/B-H/DI A B- C 1B ITJ BYZ1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 28(9),23,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,798,1977

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盐酸金刚乙胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU4717000

[ 海关编码 ]:
2921199090

盐酸金刚乙胺合成路线

盐酸金刚乙胺上下游产品

盐酸金刚乙胺上游产品

盐酸金刚乙胺下游产品

盐酸金刚乙胺制备

【方法1】
制法溴化金刚烷在三溴化铝催化下，和溴乙烯加成。生成物和氢氧化钾加热消除二分子的溴化氢，得到乙炔化物。再在氧化汞催化下，和硫酸水合得到酮，接着和羟胺成肟，最后用氢化铝锂还原(或在Pd/C下催化加氢)，得到金刚乙胺。

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盐酸金刚乙胺海关

[ 海关编码 ]: 2921300090

[ 中文概述 ]:
2921300090 其他环（烷，烯，萜烯）单胺或多胺（包括其衍生物及它们的盐）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

盐酸金刚乙胺文献

Exploring the proton conductance and drug resistance of BM2 channel through molecular dynamics simulations and free energy calculations at different pH conditions.

J. Phys. Chem. B 117(4) , 982-8, (2013)

BM2 channel plays an important role in the replication of influenza virus B. However, few studies attempt to investigate the mechanism of the proton conductance in BM2 channel, as well as the drug res...

Cys-Loop Receptor Channel Blockers Also Block GLIC

Biophys. J. 101(12) , 2912-8, (2011)

The Gloeobacter ligand-gated ion channel (GLIC) is a bacterial homolog of vertebrate Cys-loop ligand-gated ion channels. Its pore-lining region in particular has a high sequence homology to these rela...

[Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture].

Antibiot. Khimioter. 56(3-4) , 3-9, (2011)

The data on cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pa...

更多文献

盐酸金刚乙胺

盐酸金刚乙胺用途

盐酸金刚乙胺名称

盐酸金刚乙胺生物活性

盐酸金刚乙胺物理化学性质

盐酸金刚乙胺MSDS

详细MSDS(安全技术说明书)

盐酸金刚乙胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

盐酸金刚乙胺安全信息

盐酸金刚乙胺合成路线

详细合成路线

盐酸金刚乙胺上下游产品

盐酸金刚乙胺上游产品

盐酸金刚乙胺下游产品

盐酸金刚乙胺制备

盐酸金刚乙胺海关

盐酸金刚乙胺文献

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