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邻甲氧基肉桂醛

邻甲氧基肉桂醛用途

2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) 是一种肉桂中的天然化合物,具有抗肿瘤活性。2-Methoxycinnamaldehyde 能通过使线粒体膜电位 (ΔΨm) 损失 、激活 caspase-3 和 caspase-9,来抑制细胞增殖和诱导细胞凋亡。2-Methoxycinnamaldehyde 能有效抑制血小板衍生生长因子诱导的 HASMC 迁移。
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邻甲氧基肉桂醛名称

[ CAS 号 ]:
1504-74-1

[ 中文名 ]:
2'-甲氧基肉桂醛

[ 英文名 ]:
o-Methoxycinnamaldehyde

[中文别名 ]:

[英文别名 ]:

邻甲氧基肉桂醛生物活性

[ 描述 ]:

2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) 是一种肉桂中的天然化合物,具有抗肿瘤活性。2-Methoxycinnamaldehyde 能通过使线粒体膜电位 (ΔΨm) 损失 、激活 caspase-3 和 caspase-9,来抑制细胞增殖和诱导细胞凋亡。2-Methoxycinnamaldehyde 能有效抑制血小板衍生生长因子诱导的 HASMC 迁移。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡
研究领域 >> 癌症

[参考文献]

[1]. Wong HY, et al. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytother Res. 2016 Feb;30(2):331-40.

[2]. Liu YH, et al. Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells. Eur J Cancer Prev. 2017 Jul;26(4):314-323.

[3]. Jin YH, et al. 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells. Int J Mol Med. 2017 Jan;39(1):191-198.

邻甲氧基肉桂醛物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
334.8±0.0 °C at 760 mmHg

[ 熔点 ]:
44-48ºC

[ 分子式 ]:
C10H10O2

[ 分子量 ]:
162.185

[ 闪点 ]:
134.4±13.9 °C

[ 精确质量 ]:
162.068085

[ PSA ]:
26.30000

[ LogP ]:
2.13

[ 外观性状 ]:
黄色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.559

[ 储存条件 ]:
室温

邻甲氧基肉桂醛MSDS

详细MSDS(安全技术说明书)

邻甲氧基肉桂醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD6590000
CHEMICAL NAME :
Cinnamaldehyde, o-methoxy-
CAS REGISTRY NUMBER :
1504-74-1
BEILSTEIN REFERENCE NO. :
2436856
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H10-O2
MOLECULAR WEIGHT :
162.20
WISWESSER LINE NOTATION :
VH1U1R BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
333 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986
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邻甲氧基肉桂醛安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
GD6590000

[ 海关编码 ]:
2912499000

邻甲氧基肉桂醛合成路线

详细合成路线

邻甲氧基肉桂醛上下游产品

邻甲氧基肉桂醛上游产品

邻甲氧基肉桂醛下游产品

邻甲氧基肉桂醛制备

由水杨醛经与硫酸二甲酯甲基化反应而制得。将3kg氢氧化钠配成30%水溶液，在搅拌下加入含12.2kg水杨醛和80L水的溶液中，加热至沸。将12.9kg硫酸二甲酯慢慢加入，使反应液保持回流约3h加完，继续回流2-3h，冷却油层，用5%氢氧化钠溶液洗涤，再用水洗至pH为8，加无水碳酸钾干燥。滤除干燥剂后减压蒸馏，收集120℃（2.0kPa）馏分，即为邻甲氧基苯甲醛。甲基化反应也可在溶剂甲苯中进行，收率60%。

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邻甲氧基肉桂醛海关

[ 海关编码 ]: 2912499000

[ 中文概述 ]:
2912499000. 其他醛醚、醛酚及含其他含氧基的醛. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

邻甲氧基肉桂醛文献

Electrophysiological and behavioral characterization of bioactive compounds of the Thymus vulgaris, Cymbopogon winterianus, Cuminum cyminum and Cinnamomum zeylanicum essential oils against Anopheles gambiae and prospects for their use as bednet treatments.

Parasit. Vectors 8 , 316, (2015)

Laboratory and field studies showed that repellent, irritant and toxic actions of common public health insecticides reduce human-vector contact and thereby interrupt disease transmission. One of the m...

Proton pumping ATPase mediated fungicidal activity of two essential oil components.

J. Basic Microbiol. 52(5) , 504-12, (2012)

This work evaluates the antifungal activity of two essential oil components against 28 clinical isolates (17 sensitive, 11 resistant) and 3 standard laboratory strains of Candida. Growth of the organi...

Comparison of adult corn rootworm (Coleoptera: Chrysomelidae) sampling methods.

J. Econ. Entomol. 95(1) , 96-105, (2002)

Studies were conducted in Kansas corn and soybean fields during 1997 to compare various sampling methods, traps, and trap components for capturing three species of adult corn rootworms: western (Diabr...


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联系人：徐经理

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价格：
￥108.0/25g ￥318.0/100g

联系人：刘佳

产品详情：邻甲氧基肉桂醛

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￥95.9/25g ￥1338.9/500g ￥277.9/100g ￥41.9/5g

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产品详情：2-甲氧基肉桂醛

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