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邻甲氧基苯甲酸

邻甲氧基苯甲酸用途

2-Methoxybenzoic acid 可被用作黄瓜叶中水杨酸以及假定生物合成前体的一个内参,另一个已知的用途是在贝珠单抗的合成中。

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邻甲氧基苯甲酸名称

[ CAS 号 ]:
579-75-9

[ 中文名 ]:
邻甲氧基苯甲酸

[ 英文名 ]:
2-Methoxybenzoic acid

[中文别名 ]:

[英文别名 ]:

2-OMeC6H4COOH
2-methoxybenzoic
2-CARBOXYANISOLE
RARECHEM AL BO 0025
2-Anisic acid
EINECS 209-447-8
o-Anisic Acid
o-Anisc Acid
Methylsalicylic acid
O-METHYLSALICYLIC ACID

邻甲氧基苯甲酸生物活性

[ 描述 ]:

2-Methoxybenzoic acid 可被用作黄瓜叶中水杨酸以及假定生物合成前体的一个内参,另一个已知的用途是在贝珠单抗的合成中。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Meuwly P, et al. Ortho-anisic acid as internal standard for the simultaneous quantitation of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Anal Biochem. 1993 Nov 1;214(2):500-5.

[相关活性小分子]

邻甲氧基苯甲酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
279.9±13.0 °C at 760 mmHg

[ 熔点 ]:
98-100 °C(lit.)

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
116.3±13.3 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
46.53000

[ LogP ]:
1.50

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
室温

邻甲氧基苯甲酸MSDS

邻甲氧基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ4385000

CHEMICAL NAME :: o-Anisic acid

CAS REGISTRY NUMBER :: 579-75-9

BEILSTEIN REFERENCE NO. :: 0509929

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QVR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

REFERENCE :: BSRSA6 Bulletin de la Societe Royale des Sciences de Liege. (Societe Royale des Sciences de Liege, Universite de Liege, 15, Ave des Tilleuls, B-4000 Liege, Belgium) V.1- 1932- Volume(issue)/page/year: 47,202,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

REFERENCE :: BSRSA6 Bulletin de la Societe Royale des Sciences de Liege. (Societe Royale des Sciences de Liege, Universite de Liege, 15, Ave des Tilleuls, B-4000 Liege, Belgium) V.1- 1932- Volume(issue)/page/year: 47,202,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,52,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 31,236,1982

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邻甲氧基苯甲酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BZ4385000

[ 海关编码 ]:
2918990090

邻甲氧基苯甲酸合成路线

邻甲氧基苯甲酸上下游产品

邻甲氧基苯甲酸上游产品

邻甲氧基苯甲酸下游产品

邻甲氧基苯甲酸制备

1. 由水杨酸与硫酸二甲酯反应而得。将水杨酸溶于氢氧化钠溶液中，冷至20℃以下，滴加入硫酸二甲酯，控制温度在20℃左右，加至一半后，同时滴加氢氧化钠溶液。加毕，于1h内升温至95℃，再滴加氢氧化钠溶液。搅拌回流6-7h。冷至室温，用浓盐酸酸化至pH值为2，放置。过滤，水洗，氢氧化钠溶液洗至pH=8-9。再加结晶乙酸钠和冰醋酸，放置后滤出邻甲氧基苯甲酸。

2. 烟草：FC，9；FC，40。

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邻甲氧基苯甲酸海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

邻甲氧基苯甲酸文献

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

Endogenous salicylic acid accumulation is required for chilling tolerance in cucumber (Cucumis sativus L.) seedlings.

Planta 240(4) , 687-700, (2014)

Salicylic acid (SA) is an important plant hormone, and its exogenous application can induce tolerance to multiple environmental stresses in plants. In this study, we examine the potential involvement ...

Purification and properties of gentisate 1,2-dioxygenase from Moraxella osloensis.

J. Bacteriol. 121(3) , 794-9, (1975)

Gentisate:oxygen 1,2-oxidoreductase (decyclizing) (EC 1.13.11.4; gentisate 1,2-dioxygenase) from Moraxella osloensis was purified to homogeneity as shown by polyacrylamide gel electrophoresis. The enz...

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邻甲氧基苯甲酸

邻甲氧基苯甲酸用途

邻甲氧基苯甲酸名称

邻甲氧基苯甲酸生物活性

邻甲氧基苯甲酸物理化学性质

邻甲氧基苯甲酸MSDS

详细MSDS(安全技术说明书)

邻甲氧基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

邻甲氧基苯甲酸安全信息

邻甲氧基苯甲酸合成路线

详细合成路线

邻甲氧基苯甲酸上下游产品

邻甲氧基苯甲酸上游产品

邻甲氧基苯甲酸下游产品

邻甲氧基苯甲酸制备

邻甲氧基苯甲酸海关

邻甲氧基苯甲酸文献

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