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BW 723C86盐酸盐

BW 723C86盐酸盐用途

BW-723C86是一种有效且选择性的5-HT2B受体激动剂。BW-723C86具有抗焦虑作用。BW-723C86还会导致大鼠贪食和梳洗减少[1][2][3]。

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BW 723C86盐酸盐名称

[ CAS 号 ]:
160521-72-2

[ 中文名 ]:
BW 723C86盐酸盐

[ 英文名 ]:
BW-723C86

[英文别名 ]:

MFCD01321066

BW 723C86盐酸盐生物活性

[ 描述 ]:

BW-723C86是一种有效且选择性的5-HT2B受体激动剂。BW-723C86具有抗焦虑作用。BW-723C86还会导致大鼠贪食和梳洗减少[1][2][3]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[ 靶点 ]

5-HT2B Receptor

[参考文献]

[1]. Kennett GA, et, al. BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology. 1997 Feb;36(2):233-9.

[2]. Kennett GA, et, al. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. 1998 Dec;37(12):1603-10.

[3]. Matsumoto T, et, al. Effect of Equol on Vasocontractions in Rat Carotid Arteries Treated with High Insulin. Biol Pharm Bull. 2019;42(6):1048-1053.

BW 723C86盐酸盐物理化学性质

[ 沸点 ]:
488.4ºC at 760 mmHg

[ 熔点 ]:
203 - 205 °C

[ 分子式 ]:
C₁₆H₁₉ClN₂OS

[ 分子量 ]:
322.853

[ 闪点 ]:
249.2ºC

[ 精确质量 ]:
322.090668

[ PSA ]:
79.28000

[ LogP ]:
5.20040

[ 外观性状 ]:
米色，白色粉末

[ 蒸汽压 ]:
1.09E-09mmHg at 25°C

[ 储存条件 ]:
室温

BW 723C86盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL8504715

[ 海关编码 ]:
2934999090

BW 723C86盐酸盐海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

BW 723C86盐酸盐文献

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.

J. Neurosci. 35 , 9580-94, (2015)

Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, des...

BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats.

Neuropharmacology 36 , 233-239, (1997)

The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min...

Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety.

Br. J. Pharmacol. 117 , 1443-1448, (1996)

1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis....

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