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替可克肽

替可克肽用途

Tetracosactide (INN) 是肾上腺皮质激素 (ACTH) 的类似物,有刺激肾上腺皮质激素分泌的生物活性。

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替可克肽名称

[ CAS 号 ]:
16960-16-0

[ 中文名 ]:
替可克肽

[ 英文名 ]:
Adrenocorticotropic Hormone Fragment 1-24 human

[中文别名 ]:

[英文别名 ]:

Cortrosyn
MFCD00167476
cosyntropin
α1-24-Corticotropin
EINECS 241-031-1
Tetracosactide
Porcine ACTH (1-24)
Tetracosactide Acetate

替可克肽生物活性

[ 描述 ]:

Tetracosactide (INN) 是肾上腺皮质激素 (ACTH) 的类似物,有刺激肾上腺皮质激素分泌的生物活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

多肽产品

[相关活性小分子]

替可克肽物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₁₃₆H₂₁₀N₄₀O₃₁S

[ 分子量 ]:
2933.437

[ 精确质量 ]:
2931.580566

[ PSA ]:
1184.02000

[ LogP ]:
-3.27

[ 折射率 ]:
1.681

[ 储存条件 ]:
−20°C

替可克肽毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GM7915000

CHEMICAL NAME :: alpha(sup 1-24)-Corticotropin

CAS REGISTRY NUMBER :: 16960-16-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C136-H210-N40-O31-S

MOLECULAR WEIGHT :: 2933.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 5 ug/kg

TOXIC EFFECTS :: Cardiac - change in rate Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 237,879,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4549 No. of Facilities: 24 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1071 (estimated) No. of Female Employees: 546 (estimated)

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替可克肽安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GM7915000

替可克肽文献

An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.

J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015)

Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M...

The relationship between vitamin D status and adrenal insufficiency in critically ill children.

J. Clin. Endocrinol. Metab. 98(5) , E877-81, (2013)

Recent studies in critically ill populations have suggested both adrenal insufficiency (AI) and vitamin D deficiency to be associated with worse clinical outcome. There are multiple mechanisms through...

Free and total plasma cortisol measured by immunoassay and mass spectrometry following ACTH₁₋₂₄ stimulation in the assessment of pituitary patients.

J. Clin. Endocrinol. Metab. 98(5) , 1883-90, (2013)

Measurement of plasma cortisol by immunoassay after ACTH₁₋₂₄ stimulation is used to assess the hypothalamic-pituitary-adrenal (HPA) axis. Liquid chromatography-tandem mass spectrometry (LCMS) has grea...

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