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9,12-Octadecadiynoic Acid

9,12-Octadecadiynoic Acid用途

Ro 3-1314(9a,12a十八炔二酸)是一种植物脂氧合酶抑制剂。Ro 3-1314是一种亚油酸代谢抑制剂。Ro 3-1314刺激抗原诱导的豚鼠气管螺旋收缩,并从主动致敏豚鼠肺碎片中免疫释放过敏反应慢反应物质(SRS-A)[1]。

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9,12-Octadecadiynoic Acid名称

[ CAS 号 ]:
2012-14-8

[ 中文名 ]:
9,12-十八碳二烯酸

[ 英文名 ]:
9,12-Octadecadiynoic acid

[英文别名 ]:

ODYA Ro 3-1314
octadeca-9,12-diynoic acid
9,12-Octadecadiynoic acid

9,12-Octadecadiynoic Acid生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

研究领域 >> 代谢疾病

[参考文献]

[1]. M Hitchcock, et al. Arachidonic acid metabolism and modulation of in vitro anaphylaxis by 5,8,11,14-eicosatetraynoic acid and 9a,12a-octadecadiynoic acid. Br J Pharmacol. 1981 Apr;72(4):689-95.

9,12-Octadecadiynoic Acid物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
424.0±30.0 °C at 760 mmHg

[ 分子式 ]:
C₁₈H₂₈O₂

[ 分子量 ]:
276.414

[ 闪点 ]:
202.1±19.2 °C

[ 精确质量 ]:
276.208923

[ PSA ]:
37.30000

[ LogP ]:
5.75

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.490

[ 储存条件 ]:
-20°C，密闭，干燥

9,12-Octadecadiynoic Acid安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2916190090

9,12-Octadecadiynoic Acid合成路线

详细合成路线

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9,12-Octadecadiynoic Acid海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

9,12-Octadecadiynoic Acid文献

Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.

Proteomics 15 , 2066-77, (2015)

Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane i...

Arachidonic acid metabolism and modulation of in vitro anaphylaxis by 5,8,11,14-eicosatetraynoic acid and 9a,12a-octadecadiynoic acid.

Br. J. Pharmacol. 72(4) , 689-95, (1981)

1. 5,8,11,14-Eicosatetraynoic acid (ETYA) inhibited the antigen-induced contractions of tracheal spirals obtained from actively sensitized guinea-pigs. Consistent data were obtained only when the spir...

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