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PPOH

PPOH用途

PPOH是一种脂肪酸衍生物,是一种选择性环氧合酶(COX)抑制剂,可抑制肾皮质微粒体中的花生四烯酸环氧合酶活性。此外,PPOH作用于CYP4A2和CYP4A3,IC50值分别为22μM和6.5μM[1]。

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PPOH名称

[ CAS 号 ]:
206052-01-9

[ 英文名 ]:
PPOH

[英文别名 ]:

Benzenehexanoic acid, α-(2-propyn-1-yloxy)-
6-Phenyl-2-(2-propyn-1-yloxy)hexanoic acid
6-(2-propargyloxyphenyl)hexanoic acid
Benzenehexanoic acid, 2-(2-propyn-1-yloxy)-
6-[2-(2-Propyn-1-yloxy)phenyl]hexanoic acid
6-(2-prop-2-ynoxyphenyl)hexanoic acid

PPOH生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 其他

信号通路 >> 免疫及炎症 >> COX

[体外研究]

PPOH(5μM)在不存在和存在30分钟NADPH预培养的情况下可分别抑制CYP2C9活性63%和90%,而在30分钟预培养中不存在NADPH时可抑制63%[1]。

[参考文献]

[1]. Melissa A VanAlstine, et al. Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450s. Drug Metab Dispos. 2011 Jul;39(7):1221-6.

PPOH物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
411.0±40.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₈O₃

[ 分子量 ]:
246.302

[ 闪点 ]:
151.1±20.8 °C

[ 精确质量 ]:
246.125595

[ PSA ]:
46.53000

[ LogP ]:
3.05

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
-20°C，密闭，干燥

PPOH安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2918990090

PPOH海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

PPOH文献

Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.

Int. J. Obes. 39 , 755-61, (2015)

Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-...

Ophiopogonin D maintains Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress.

Acta Pharmacol. Sin. 37 , 368-81, (2016)

CYP2J3 in myocardium metabolizes arachidonic acid to 4 regioisomeric epoxyeicosatrienoic acids (EETs), which have diverse biological activities in rat heart. In this study we examined whether CYP2J3 w...

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