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1-(3-氯苯基)双胍盐酸盐

1-(3-氯苯基)双胍盐酸盐用途

m-CPBG(1-(3-氯苯基)双胍)盐酸盐是一种选择性5-HT3激动剂。m-CPBG盐酸盐可用于神经系统疾病的研究[1]。

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1-(3-氯苯基)双胍盐酸盐名称

[ CAS 号 ]:
2113-05-5

[ 中文名 ]:
1-(3-氯苯基)双胍

[ 英文名 ]:
1-(3-chlorophenyl)biguanide hydrochloride

[中文别名 ]:

1-(3-氯苯基)双胍盐酸盐

[英文别名 ]:

1-(3-Chlorophenyl)biguanide hydrochloride
m-Chlorophenylbiguanide hydrochloride
MFCD00053019
N-m-Chlorophenylbiguanide hydrochloride
m-CPBG hydrochloride

1-(3-氯苯基)双胍盐酸盐生物活性

[ 描述 ]:

m-CPBG(1-(3-氯苯基)双胍)盐酸盐是一种选择性5-HT3激动剂。m-CPBG盐酸盐可用于神经系统疾病的研究[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[体内研究]

m-CPBG盐酸盐(80和160 nM)显著减少急性盐负荷引起的水摄入量[1] m-CPBG盐酸盐(第三脑室注射；160 nM)显著抑制低血容量动物的水摄入[1] m-CPBG盐酸盐(第三脑室注射；320 nM)减少缺水大鼠的水摄入量[1] m-CPBG盐酸盐(中央给药)抑制中枢胆碱能和血管紧张素能通路药理学激活诱导的水摄入[1] 动物模型：Wistar雄性大鼠[1]剂量：80、160和320 nM给药：脑室注射结果：缺水、急性盐负荷和低血容量导致的水摄入量减少。

[参考文献]

[1]. Castro L, et al. Central 5-HT(3) receptors and water intake in rats. Physiol Behav. 2002;77(2-3):349-359.

1-(3-氯苯基)双胍盐酸盐物理化学性质

[ 密度 ]:
1.49g/cm3

[ 沸点 ]:
434.1ºC at 760mmHg

[ 熔点 ]:
190-194 °C(lit.)

[ 分子式 ]:
C₈H₁₁Cl₂N₅

[ 分子量 ]:
248.11

[ 闪点 ]:
216.3ºC

[ 精确质量 ]:
247.03900

[ PSA ]:
97.78000

[ LogP ]:
3.33540

[ 外观性状 ]:
solid | white

[ 蒸汽压 ]:
9.74E-08mmHg at 25°C

[ 储存条件 ]:
Desiccate at RT

[ 水溶解性 ]:
H2O: soluble

1-(3-氯苯基)双胍盐酸盐MSDS

详细MSDS(安全技术说明书)

1-(3-氯苯基)双胍盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1780000

CHEMICAL NAME :: Biguanide, 1-(m-chlorophenyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 2113-05-5

LAST UPDATED :: 199007

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H10-Cl-N5.Cl-H

MOLECULAR WEIGHT :: 248.14

WISWESSER LINE NOTATION :: MUYZMYUM&MR CG &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 186 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,521,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Endocrine - hyperglycemia

REFERENCE :: IJOCAP Indian Journal of Chemistry. (New Delhi, India) V.1-13, 1963-75. Divided into Indian Journal of Chemistry, Section A and Indian Journal of Chemistry, Section B. Volume(issue)/page/year: 1,218,1962

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1-(3-氯苯基)双胍盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DU1780000

1-(3-氯苯基)双胍盐酸盐合成路线

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