石蒜碱内铵盐

石蒜碱内铵盐用途

Ungeremine，一种从 Pancratium Illyricum 提取的菲啶类生物碱。Ungeremine 有效地靶向哺乳动物以及细菌的 I 型和 II 型拓扑异构酶。Ungeremine 对 9 种癌细胞系表现出细胞毒活性，包括药物敏感性和 MDR 表型。Ungeremine 诱导铁营养症、坏死、自噬以及caspase激活介导的细胞凋亡、MMP 改变和 ROS 生成增加。

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石蒜碱内铵盐名称

[ CAS 号 ]:
2121-12-2

[ 中文名 ]:
石蒜碱内铵盐

[ 英文名 ]:
Lycobetaine(Ungeremine)

[中文别名 ]:

恩其明

[英文别名 ]:

Ungerimine

石蒜碱内铵盐生物活性

[ 描述 ]:

Ungeremine,一种从 Pancratium Illyricum 提取的菲啶类生物碱。Ungeremine 有效地靶向哺乳动物以及细菌的 I 型和 II 型拓扑异构酶。Ungeremine 对 9 种癌细胞系表现出细胞毒活性,包括药物敏感性和 MDR 表型。Ungeremine 诱导铁营养症、坏死、自噬以及caspase激活介导的细胞凋亡、MMP 改变和 ROS 生成增加。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

信号通路 >> 细胞凋亡 >> Ferroptosis

信号通路 >> 细胞凋亡 >> 胱天蛋白酶

信号通路 >> 自噬 >> 自噬

[参考文献]

[1]. Casu L, et al. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.

[2]. Mbaveng A, et al. Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy. Phytomedicine. 2019 Jul;60:152832.

石蒜碱内铵盐物理化学性质

[ 熔点 ]:
270-272ºC (dec.)

[ 分子式 ]:
C₁₆H₁₂NO₃

[ 分子量 ]:
266.27100

[ 精确质量 ]:
266.08200

[ PSA ]:
42.57000

[ LogP ]:
2.27090

[ 储存条件 ]:
-20°C，密闭，干燥

石蒜碱内铵盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL2827500

CHEMICAL NAME :: Lycoranium, 1,2,3,3a,6,7,12b,12c-octadehydro-2-hydroxy-

CAS REGISTRY NUMBER :: 2121-12-2

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H12-N-O3

MOLECULAR WEIGHT :: 266.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,316,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,316,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 75 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 54,114,1988