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尼芬那宗

尼芬那宗用途

Nifenazone 是一种吡唑类药物,可用于治疗各种风湿性疾病。

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尼芬那宗名称

[ CAS 号 ]:
2139-47-1

[ 中文名 ]:
尼芬那宗

[ 英文名 ]:
Nifenazone

[中文别名 ]:

烟酰氨基比林

[英文别名 ]:

Nicotazone
nifenazone
Nicoreumal
Nicazane
niphenazone
1,5-Dimethyl-4-nicotinamido-2-phenyl-3-pyrazolone
Nicodone
Nicophesone
Niapyrin
Nicofesone

尼芬那宗生物活性

[ 描述 ]:

Nifenazone 是一种吡唑类药物,可用于治疗各种风湿性疾病。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. HART FD, et al. TRIAL OF NIFENAZONE ("THYLIN"). Br Med J. 1964 Jun 13;1(5397):1553-4.

[2]. Bani-Yaseen AD, et al. The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study. Phys Chem Chem Phys. 2014 Aug 7;16(29):15519-26.

[相关活性小分子]

尼芬那宗物理化学性质

[ 密度 ]:
1.33g/cm3

[ 熔点 ]:
252-253° (also reported as mp 256-258°)

[ 分子式 ]:
C₁₇H₁₆N₄O₂

[ 分子量 ]:
308.33500

[ 精确质量 ]:
308.12700

[ PSA ]:
68.92000

[ LogP ]:
2.20470

[ 折射率 ]:
1.671

[ 储存条件 ]:
2-8°C

尼芬那宗MSDS

详细MSDS(安全技术说明书)

尼芬那宗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS4005000

CHEMICAL NAME :: Nicotinamide, N-antipyrinyl-

CAS REGISTRY NUMBER :: 2139-47-1

BEILSTEIN REFERENCE NO. :: 0307504

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H16-N4-O2

MOLECULAR WEIGHT :: 308.37

WISWESSER LINE NOTATION :: T6NJ CVM- DT5NNVJ A1 BR& E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7890 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 12,235,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1280 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,132,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78. For publisher information, see IJSIDW. Volume(issue)/page/year: 26,99,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 4,89,1972

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尼芬那宗安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
QS4005000

[ 海关编码 ]:
2933990090

尼芬那宗合成路线

详细合成路线

尼芬那宗上下游产品

尼芬那宗上游产品

尼芬那宗下游产品

尼芬那宗海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

尼芬那宗文献

Temporal endogenous gene expression profiles in response to lipid-mediated transfection.

J. Gene Med. 17(1-2) , 14-32, (2015)

Design of efficient nonviral gene delivery systems is limited as a result of the rudimentary understanding of the specific molecules and processes that facilitate DNA transfer.Lipoplexes formed with L...

[Nifenazone, biotransformation in humans].

Arch. Pharm. (Weinheim) 318(9) , 855-63, (1985)

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