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8-姜酚

8-姜酚用途

8-Gingerol 来源于姜的根状茎 (Z. officinale),具有口服活性,可激活 TRPV1,EC50 值为5.0 µM。8-Gingerol 抑制COX-2,还能抑制体外 H. pylori 的生长。

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8-姜酚名称

[ CAS 号 ]:
23513-08-8

[ 中文名 ]:
[8]-姜酚

[ 英文名 ]:
8-Gingerol

[中文别名 ]:

[英文别名 ]:

8-Gingerol

8-姜酚生物活性

[ 描述 ]:

8-Gingerol 来源于姜的根状茎 (Z. officinale),具有口服活性,可激活 TRPV1,EC50 值为5.0 µM。8-Gingerol 抑制COX-2,还能抑制体外 H. pylori 的生长。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 感染

研究领域 >> 炎症/免疫

[参考文献]

[1]. Dedov, V.N., et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br. J. Pharmacol. 137(6), 793-798 (2002).

[2]. Chrubasik, S., et al. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12(9), 684-701 (2005).

8-姜酚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
476.4±35.0 °C at 760 mmHg

[ 熔点 ]:
30 - 32 °C

[ 分子式 ]:
C₁₉H₃₀O₄

[ 分子量 ]:
322.439

[ 闪点 ]:
162.6±19.4 °C

[ 精确质量 ]:
322.214417

[ PSA ]:
66.76000

[ LogP ]:
3.55

[ 外观性状 ]:
油性固体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.517

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
methanol: soluble1mg/mL, clear, colorless

8-姜酚MSDS

8-姜酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR4362000

CHEMICAL NAME :: 3-Dodecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-

CAS REGISTRY NUMBER :: 23513-08-8

LAST UPDATED :: 199503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H30-O4

MOLECULAR WEIGHT :: 322.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 25,231,1990

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8-姜酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
43

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

[ RTECS号 ]:
JR4362000

[ 海关编码 ]:
29145019

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8-姜酚文献

Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 986-987 , 69-84, (2015)

Gua-Lou-Gui-Zhi decoction (GLGZD) is a classical formula of traditional Chinese medicine, which has been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury. In this study...

Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.

J. Pharm. Pharmacol. 67(4) , 583-96, (2015)

To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and ...

Identification of serotonin 5-HT1A receptor partial agonists in ginger.

Bioorg. Med. Chem. 18 , 3345-51, (2010)

Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the hu...

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