< 生产厂家价格 >

terameprocol

terameprocol用途

Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。

点击显示

terameprocol名称

[ CAS 号 ]:
24150-24-1

[ 英文名 ]:
terameprocol

[英文别名 ]:

terameprocol
tetramethyl Nordihydroguaiaretic Acid Exclusive
tetramethyl Nordihydroguaiaretic Acid

terameprocol生物活性

[ 描述 ]:

Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[参考文献]

[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000.

[2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7.

[3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9.

terameprocol物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
458.5±40.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₃₀O₄

[ 分子量 ]:
358.471

[ 闪点 ]:
108.8±34.2 °C

[ 精确质量 ]:
358.214417

[ PSA ]:
36.92000

[ LogP ]:
5.86

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.522

[ 储存条件 ]:
-20°C，密闭，干燥

terameprocol安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

terameprocol上下游产品

terameprocol上游产品

terameprocol下游产品

terameprocol文献

Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.

Drugs 3rd ed., 11 , 204-214, (2008)

Terameprocol, a novel, semisynthetic derivative of a naturally occurring plant lignan, is under development by Erimos Pharmaceuticals LLC for the potential treatment of cancer. The antitumor activity ...

Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.

PLoS ONE 11 , e0148685, (2016)

The ability of Tetra-O-methyl nordihydroguaiaretic acid (M4N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in LNCaP cells, both in cell culture and anima...

Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials.

ACS Appl. Mater. Interfaces 5 , 7509-16, (2013)

To develop a drug delivery system (DDS), it is critical to address challenging tasks such as the delivery of hydrophobic and amphiphilic compounds, cell uptake, and the metabolic fate of the drug deli...

更多文献