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Minaprine dihydrochloride

Minaprine dihydrochloride用途

Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。

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Minaprine dihydrochloride名称

[ CAS 号 ]:
25953-17-7

[ 中文名 ]:
4-甲基-N-(2-吗啉-4-乙基)-6-苯基吡嗪-3-胺

[ 英文名 ]:
Minaprine (dihydrochloride)

[英文别名 ]:

Ag 620
Agr 620
Agr 1240
Minaprine (dihydrochloride)

Minaprine dihydrochloride生物活性

[ 描述 ]:

Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

[参考文献]

[1]. Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8.

[2]. Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41.

[相关活性小分子]

Minaprine dihydrochloride物理化学性质

[ 沸点 ]:
531.2ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₂₄Cl₂N₄O

[ 分子量 ]:
371.30

[ 闪点 ]:
275.1ºC

[ PSA ]:
50.28000

[ LogP ]:
3.00900

[ 蒸汽压 ]:
2.29E-11mmHg at 25°C

[ 储存条件 ]:
2-8℃

Minaprine dihydrochloride毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE3477835

CHEMICAL NAME :: 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 25953-17-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H22-N4-O.2Cl-H

MOLECULAR WEIGHT :: 371.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4823 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Endocrine - changes in thymus weight

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990