异三尖杉酯碱

异三尖杉酯碱用途

异三尖杉酯碱是一种天然生物碱,可从三尖杉中提纯。异三尖杉酯碱能抑制癌症细胞增殖和迁移,诱导癌症细胞凋亡。异三尖杉酯碱可用于癌症研究[1][2]。

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异三尖杉酯碱名称

[ CAS 号 ]:
26833-86-3

[ 中文名 ]:
异三尖杉酯碱

[ 英文名 ]:
Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate]

[英文别名 ]:

iso-harringtonine

异三尖杉酯碱生物活性

[ 描述 ]:

异三尖杉酯碱是一种天然生物碱,可从三尖杉中提纯。异三尖杉酯碱能抑制癌症细胞增殖和迁移,诱导癌症细胞凋亡。异三尖杉酯碱可用于癌症研究[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Lee JH, et al. Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway. Biomolecules. 2020 Nov 6;10(11):1521.

[2]. Chen W, et al. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. Biomed Pharmacother. 2018 Jul;103:435-442.

异三尖杉酯碱物理化学性质

[ 密度 ]:
1.35g/cm3

[ 沸点 ]:
632.5ºC at 760mmHg

[ 熔点 ]:
70.75°C

[ 分子式 ]:
C₂₈H₃₇NO₉

[ 分子量 ]:
531.59500

[ 精确质量 ]:
531.24700

[ PSA ]:
123.99000

[ LogP ]:
1.98440

[ 蒸汽压 ]:
7.21E-17mmHg at 25°C

[ 折射率 ]:
1.607

异三尖杉酯碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR2935500

CHEMICAL NAME :: Isoharringtonine

CAS REGISTRY NUMBER :: 26833-86-3

LAST UPDATED :: 198909

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C28-H37-N-O9

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27950 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26110 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988