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α-常春藤皂苷

α-常春藤皂苷用途

alpha-hederin是能够水溶的五环三萜皂苷,有很多化学特性,例如止痉挛,驱虫,和抑制细胞增长。

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α-常春藤皂苷名称

[ CAS 号 ]:
27013-91-8

[ 中文名 ]:
Alpha-常春藤苷

[ 英文名 ]:
alpha-Hederin

[中文别名 ]:

[英文别名 ]:

α-Hederin
Alpha-hederin
glycosidel-e1
UNII:4H15F0GLV2
sapindosidea
HELIXIN
nepalin2
dipsacobioside
Hederoside B
koronaroside A

α-常春藤皂苷生物活性

[ 描述 ]:

alpha-hederin是能够水溶的五环三萜皂苷,有很多化学特性,例如止痉挛,驱虫,和抑制细胞增长。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 萜类化合物和糖苷

研究领域 >> 其他

[参考文献]

[1]. Danloy S et al. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med, 1994 Feb, 60(1):45-9.

[2]. Maryam Fallahi et al. Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats. Planta Med, 1994 Feb, 60(1):45-9.

[相关活性小分子]

α-常春藤皂苷物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
849.6±65.0 °C at 760 mmHg

[ 熔点 ]:
215ºC (dec.)

[ 分子式 ]:
C₄₁H₆₆O₁₂

[ 分子量 ]:
750.956

[ 闪点 ]:
250.7±27.8 °C

[ 精确质量 ]:
750.455444

[ PSA ]:
195.60000

[ LogP ]:
8.37

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
2~8℃

α-常春藤皂苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RK0177800

CHEMICAL NAME :: Olean-12-en-28-oic acid, 3-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arab inopyranosyl) oxy)-23-hydroxy-, (3-beta,4-alpha)-

CAS REGISTRY NUMBER :: 27013-91-8

BEILSTEIN REFERENCE NO. :: 0076156

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C41-H66-O12

MOLECULAR WEIGHT :: 751.07

WISWESSER LINE NOTATION :: L F6 E6 B666 CUTJ F1 J1Q J1 N1 O1 RVQ U1 U1 IO- BT6OTJ DQ EQ CO- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980

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α-常春藤皂苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
22-45-24/25

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
RK0177800

α-常春藤皂苷合成路线

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α-常春藤皂苷文献

Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin.

J. Biol. Chem. 288(20) , 14000-17, (2013)

The interactions of triterpenoid monodesmosidic saponins, α-hederin and δ-hederin, with lipid membranes are involved in their permeabilizing effect. Unfortunately, the interactions of these saponins w...

Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.

Biochemistry 48(15) , 3477-82, (2009)

Hederacoside C, alpha-hederin, and hederagenin are saponins of dry extracts obtained from the leaves of ivy (Hedera helix L.). Internalization of beta(2)-adrenergic receptor-GFP fusion proteins after ...

Participation of cholinergic pathways in α-hederin-induced contraction of rat isolated stomach strips.

Phytomedicine 19(7) , 591-5, (2012)

The dry extract of Hedra helix leaves and its main active compounds, predominantly α-hederin and hederacoside C, has been traditionally believed to act spasmolytic. However, it has been recently prove...

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