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咪唑

咪唑用途

Imidazole是一种平面五元环, 是一种高极性化合物, 已被广泛用作腐蚀抑制剂
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咪唑名称

[ CAS 号 ]:
288-32-4

[ 中文名 ]:
咪唑

[ 英文名 ]:
Imidazole

[中文别名 ]:

[英文别名 ]:

咪唑生物活性

咪唑物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
257.0±9.0 °C at 760 mmHg

[ 熔点 ]:
88-91 °C(lit.)

[ 分子式 ]:
C3H4N2

[ 分子量 ]:
68.077

[ 闪点 ]:
145.0±0.0 °C

[ 精确质量 ]:
68.037445

[ PSA ]:
28.68000

[ LogP ]:
-0.16

[ 外观性状 ]:
白色至黄色晶体或粉末,带有一种胺的气味

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture.

[ 水溶解性 ]:
633 g/L (20 ºC)

咪唑MSDS

咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI3325000
CHEMICAL NAME :
Imidazole
CAS REGISTRY NUMBER :
288-32-4
BEILSTEIN REFERENCE NO. :
0103853
LAST UPDATED :
199710
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C3-H4-N2
MOLECULAR WEIGHT :
68.09
WISWESSER LINE NOTATION :
T5M CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
626 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
880 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
817 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
475 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - rigidity (including catalepsy) Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
150 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - impotence

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
1 mmol/L
REFERENCE :
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1601 No. of Facilities: 158 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1401 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1601 No. of Facilities: 313 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 3009 (estimated) No. of Female Employees: 2411 (estimated)
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咪唑安全信息

[ 符号 ]:

GHS05, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H360D

[ 警示性声明 ]:
P201-P260-P280-P303 + P361 + P353-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R22;R34;R63

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S22-S36

[ 危险品运输编码 ]:
UN 2923 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
NI3325000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2933990090

咪唑合成路线

咪唑上下游产品

咪唑制备

由乙二醛经环合;中和而得。将乙二醛、甲醛、硫酸铵投入反应锅,搅拌加热至85-88℃,保温4h。冷至50-60℃,用石灰水中和至pH为10以上。加热至85-90℃,排氨1h以上,稍冷,过滤,滤饼用热水洗涤,合并洗;滤液,减压浓缩至无水蒸出时,继续减压蒸馏至低沸物全部蒸完,收集105-160℃(0.133-0.267kPa)馏分,得咪唑。收率约45%。

另一种制法是使邻苯二胺与甲酸环合生成苯骈咪唑,再经双氧水反应开环为4,5-二羟基咪唑,最后脱羧制得咪唑。4,5-二羟基咪唑也可由d-酒石酸经硝化、环合而得。4,5-二羧基咪唑的脱羧制取咪唑的工艺过程如下:将4,5-二羟基咪唑与氧化铜混合,加热至100-280℃,放出大量二氧化碳气体,收集馏出液即得粗品,用苯重结晶得成品,收率76%。

3.咪唑的化学合成路线有乙二醛合成法、腈类合成法、酒石酸法、邻苯二胺与甲酸环合法、溴乙醛法等。

(1)工业乙二醛合成法 将乙二醛、甲醛、硫酸铵投入反应釜,搅拌加热至85~88℃,保温4h。然后冷却至50~60℃,用石灰水中和至pH值10以上,再加热至85~90℃,排氨1h以上。稍冷后,过滤,滤饼用热水洗涤,合并洗、滤液,加入到蒸馏装置中,先减压浓缩至无水蒸出,再继续减压蒸馏至低沸物全部蒸完,然后收集105~160℃/133.3~266.7Pa馏分,得咪唑。收率约45%。每吨产品消耗乙二醛4172kg,甲醛(37%)2344kg,硫酸铵(99%)3826kg,石灰2571kg。反应式如下:

该法由于收率和产品质量不尽如人意,文献报道了一些改进方法,如采用异丙醚萃取的方法、用乌洛托品代替甲醛的合成方法、用氨水代替硫酸铵的合成方法、用草酸铵代替硫酸铵的合成方法等。如用草酸铵代替硫酸铵可使收率提高到65%。

4.邻苯二胺与甲酸环合法 将邻苯二胺与甲酸环合生成苯并咪唑,再经双氧水反应开环为4,5-二羧基咪唑,最后脱羧制得咪唑


5.溴乙醛法 用醋酸乙烯酯与溴加成,再用乙醇处理,生成溴代乙醛,再与溴化氢、乙醇作用生成缩醛。缩醛在乙二醇及浓盐酸作用下生成环状缩醛,用过量甲酰胺与缩醛在不断通入氨气情况下反应,生成咪唑,产率为50%。

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咪唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

咪唑文献

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.

Angiogenesis 18(2) , 209-17, (2015)

Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1) is a type I BMP/TGF-β receptor that mediates signalling in endothelial cells via phosphorylation of SMAD1/5/8. During angiogenesis, sp...

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Drug Des. Devel. Ther. 9 , 1555-84, (2015)

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN823...

Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.

J. Biol. Chem. 290(16) , 10000-17, (2015)

Defining the conformational states of cytochrome P450 active sites is critical for the design of agents that minimize drug-drug interactions, the development of isoform-specific P450 inhibitors, and t...


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相关化工产品/化学物质:

推荐生产厂家/供应商:

公司名:南通润丰石油化工有限公司

区域:南通市崇川区

价格:
¥需询单/1kg ¥需询单/1ton

联系人:曹经理

产品详情:咪唑


公司名:上海吉至生化科技有限公司

区域:上海市奉贤区

价格:
¥148.0/500g

联系人:刘佳

产品详情:咪唑


公司名:上海源溪生物科技有限公司

区域:上海市浦东新区

价格:
¥需询单/1g

联系人:赖经理

产品详情:Imidazole;1,3-diazole; glyoxaline; 1,3-diazacyclopenta-2,4-diene


公司名:上海脉铂医药科技有限公司

区域:上海市嘉定区

价格:
¥789.0/10g ¥489.0/5g ¥需询单/1g ¥需询单/1g

联系人:李先生

产品详情:Imidazole


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥2274.9/6000g ¥358.9/100g ¥1432.9/500g ¥1552.9/500g

联系人:阿拉丁李高志

产品详情:咪唑


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相关化合物

【咪唑】化源网提供咪唑CAS号288-32-4,咪唑MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询咪唑上化源网,专业又轻松。>>电脑版:咪唑

标题:咪唑_MSDS_用途_密度_咪唑CAS号【288-32-4】_化源网 地址:https://m.chemsrc.com/mip/cas/288-32-4_332309.html