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N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]-苯磺酰胺

用途

T0901317 是有效,选择性的 LXR 和 FXR 激动剂,EC50 分别为50 nM 和 5 μM。

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名称

[ CAS 号 ]:
293754-55-9

[ 中文名 ]:
N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]-苯磺酰胺

[ 英文名 ]:
T0901317

[中文别名 ]:

盐酸他克林

[英文别名 ]:

MFCD03412028
T0901317

生物活性

[ 描述 ]:

T0901317 是有效,选择性的 LXR 和 FXR 激动剂,EC50 分别为50 nM 和 5 μM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> FXR

信号通路 >> 代谢酶/蛋白酶 >> LXR

研究领域 >> 癌症

[参考文献]

[1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96

[2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
470.5±55.0 °C at 760 mmHg

[ 熔点 ]:
116-122° C

[ 分子式 ]:
C₁₇H₁₂F₉NO₃S

[ 分子量 ]:
481.333

[ 闪点 ]:
238.4±31.5 °C

[ 精确质量 ]:
481.039429

[ PSA ]:
65.99000

[ LogP ]:
4.82

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.491

[ 储存条件 ]:
-20°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport.

J. Nutr. Biochem. 26(2) , 165-72, (2015)

High-density lipoproteins (HDLs) are atheroprotective because of their role in reverse cholesterol transport. The intestine is involved in this process because it synthesizes HDL, removes cholesterol ...

RNA binding protein HuR regulates the expression of ABCA1.

J. Lipid Res. 55(6) , 1066-1076, (2014)

ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA...

Effect of compounds affecting ABCA1 expression and CETP activity on the HDL pathway involved in intestinal absorption of lutein and zeaxanthin.

Lipids 49(12) , 1233-43, (2014)

The antioxidant xanthophylls lutein and zeaxanthin are absorbed from the diet in a process involving lipoprotein formation. Selective mechanisms exist for their intestinal uptake and tissue-selective ...

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