< 生产厂家价格 >

U18666A

U18666A用途

U18666A,一个细胞渗透性药物,是胆固醇合成和转运的抑制剂。

点击显示

U18666A名称

[ CAS 号 ]:
3039-71-2

[ 中文名 ]:
U18666A

[ 英文名 ]:
U-18666A

[英文别名 ]:

U18666A生物活性

[ 描述 ]:

U18666A,一个细胞渗透性药物,是胆固醇合成和转运的抑制剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

研究领域 >> 感染

[ 靶点 ]

Cholesterol[1][2].

[体外研究]

U18666A,发现抗病毒作用是由两个事件引起的：加载胆固醇的晚期内体/溶酶体中的病毒运输延迟和在处理的感染细胞中抑制从头甾醇生物合成。还观察到U18666A与脂肪酸合成酶抑制剂C75的加性抗病毒作用,表明登革病毒依赖宿主胆固醇和脂肪酸生物合成来成功复制[1] [2]。

[参考文献]

[1]. Poh MK, et al. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Res. 2012 Jan;93(1):191-8.

[2]. Cenedella RJ, et al. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 2009 Jun;44(6):477-87.

[相关活性小分子]

U18666A物理化学性质

[ 分子式 ]:
C₂₅H₄₂ClNO₂

[ 分子量 ]:
424.060

[ 精确质量 ]:
423.290405

[ PSA ]:
29.54000

[ LogP ]:
6.04730

[ 储存条件 ]:
2-8℃

U18666AMSDS

详细MSDS(安全技术说明书)

U18666A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

U18666A文献

Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.

Autophagy 10(7) , 1241-55, (2014)

Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazol...

Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.

J. Biol. Chem. 288(5) , 3136-52, (2013)

Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is charac...

Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.

PLoS ONE 7 , e30051, (2012)

A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fib...

更多文献