盐酸环胞苷
盐酸环胞苷用途
生产滴眼液。
【用途2】
抗肿瘤药。不良反应和阿糖胞苷相似,但较轻。有骨髓抑制作用。白细胞、血小板减少。用量大时常出现腮腺痛,局部冷敷可使疼痛减轻。有时可见流涎,有时可见体位性低血压、结膜充血、鼻黏膜肿胀,个别病人出现头痛、皮疹,偶可引起一过性肺部炎症变化。用药期间应严格检查血象。
【用途3】
对各种类型急性白血病及脑膜白血病均有效
盐酸环胞苷名称
[ CAS 号 ]:
10212-25-6
[ 中文名 ]:
盐酸环胞苷
[ 英文名 ]:
Cyclocytidine Hydrochloride
[中文别名 ]:
[英文别名 ]:
- Cyclocytidine Hydrochloride
- 2,2'-O-Cyclocytidine Hydrochloride
- Ancitabine Hydrochloride
- EINECS 233-515-6
- MFCD00012636
- (-)-Cyclocytidine hydrochloride
- Ancitabine (hydrochloride)
盐酸环胞苷生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
盐酸环胞苷物理化学性质
[ 密度 ]:
2.01 g/cm3
[ 沸点 ]:
442ºC at 760 mmHg
[ 熔点 ]:
269-270ºC
[ 分子式 ]:
C9H12ClN3O4
[ 分子量 ]:
261.662
[ 闪点 ]:
221.1ºC
[ 精确质量 ]:
261.051636
[ PSA ]:
100.59000
[ 外观性状 ]:
白色固体
[ 折射率 ]:
-21 ° (C=2, H2O)
[ 储存条件 ]:
室温,干燥,密封
盐酸环胞苷MSDS
盐酸环胞苷毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LV2615000
- CAS REGISTRY NUMBER :
- 10212-25-6
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C9-H11-N3-O4.Cl-H
- MOLECULAR WEIGHT :
- 261.69
- WISWESSER LINE NOTATION :
- T B555 AN CO GO IN JHTT&J D1Q EQ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 820 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2528 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 344 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 1045 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 560 mg/kg/7D-I
- TOXIC EFFECTS :
- Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 1120 mg/kg/7D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 800 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 8250 mg/kg
- SEX/DURATION :
- male 2 year(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 8-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 8-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 125 mg/kg
- SEX/DURATION :
- female 8-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - body wall
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 20,2286,1972
盐酸环胞苷安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xi
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
LV2615000
盐酸环胞苷上下游产品
盐酸环胞苷上游产品
盐酸环胞苷下游产品
盐酸环胞苷制备
以葡萄糖酸钙为原料
D-阿拉伯糖的制备 投料为葡萄糖酸钙(m):水(V):过氧化氢(30%,V):葡萄糖酸铁水溶液(10%,V):95%乙醇(V)=1:8.1:0.88:0.22:0.3。将葡萄糖酸钙投入90℃水中,加热至沸腾。搅拌10min后降温至70℃,加入葡萄糖酸铁。搅拌10min后降温至65℃,每隔20min加一次过氧化氢,6h内加完,其间保持温度为60-65℃。反应完成后冷却,过滤,将滤液通过强酸性苯乙烯系阳离子交换树脂007×7(732)和强碱性季铵I型阴离子交换树脂201×7(717),当流出液对斐林试液呈阳性反应时开始收集。收集液于60℃以下减压浓缩,加95%乙醇,放置过夜,过滤,干燥,得产品。
葡萄糖酸钙[葡萄糖酸铁,过氧化氢]→[60-65℃, 6h]D-阿拉伯糖
2-氨基-β-D-阿拉伯糖噁唑啉的制备 投料比为D-阿拉伯糖(m):氰胺(V):25%-28%氨水(V):甲醇(V)=1:0.29:0.5:3。将D-阿拉伯糖、氰胺、甲醇-氨水溶液加热,于40-45℃反应4h,冷却过夜后过滤,得产品。
D-阿拉伯糖[氰胺,氨水,甲醇]→[40-45℃, 4h]2-氨基-β-D-阿拉伯糖噁唑啉
环胞苷盐酸盐的制备 投料体积比为2-氨基-β-D-阿拉伯糖噁唑啉(V):丙炔氰:5%盐酸甲醇溶液=1:0.59:4.83。将2-氨基-β-D-阿拉伯糖噁唑啉加5%盐酸甲醇溶液成盐酸盐后,加丙炔氰于60℃反应1h,冷却,抽滤,得粗品。用3倍量的水-95%乙醇(1:2.5)重结晶,得环胞苷盐酸盐纯品。
2-氨基-β-D-阿拉伯糖噁唑啉[丙炔氰,盐酸-甲醇]→[60℃, 1h]环胞苷盐酸盐。
【方法2】
D-阿拉伯糖与氰氨、甲醇、氨水在40-45℃反应4小时,生成2-氨基-β-D-阿拉伯糖噁唑啉,将其与盐酸制成盐酸盐,与丙炔腈在60℃反应1小时,即生成环胞苷盐酸盐,总收率68%。
盐酸环胞苷文献
Br. J. Cancer 108(4) , 983-92, (2013)
DNA mismatch repair deficiency is present in a significant proportion of a number of solid tumours and is associated with distinct clinical behaviour.To identify the therapeutic agents that might show...
Tyramine-like effect of cyclocytidine (2,2'-anhydro-1-β-arabinofuranosylcytosine hydrochloride), an antineoplastic agent Oguro, K., Hashimoto, K.J. Exp. Med. 124 , 83-90, (1978)
推荐生产厂家/供应商:
公司名:上海化源生化科技有限公司
区域:上海市普陀区
价格:
联系人:化源网
产品详情:盐酸环胞苷
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥1268.0/5g
¥408.0/1g
联系人:刘佳
产品详情:盐酸环胞苷
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Ancitabine HCl
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥589.0/200mg
¥829.0/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Cyclocytidine HCl
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥95.9/1g
¥914.9/25g
¥251.9/5g
¥2702.9/100g
联系人:阿拉丁
产品详情:盐酸环胞苷
公司名:中山市迪欣化工有限公司
区域:中山市三角镇
价格:
¥1850.0/25kg
联系人:董生
产品详情:盐酸环胞苷
公司名:武汉敬康恩生物医药科技有限公司
区域:武汉市东西湖区
价格:
¥需询单/100g
¥需询单/500g
联系人:周经理
产品详情:盐酸环胞苷;安西他滨盐酸盐;环胞啶盐酸盐;环胞苷盐酸盐
查看所有供应商请点击:
相关化合物
【盐酸环胞苷】化源网提供盐酸环胞苷CAS号10212-25-6,盐酸环胞苷MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询盐酸环胞苷上化源网,专业又轻松。>>电脑版:盐酸环胞苷
标题:盐酸环胞苷_MSDS_用途_密度_盐酸环胞苷CAS号【10212-25-6】_化源网 地址:https://m.chemsrc.com/mip/cas/10212-25-6_895201.html