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非诺洛芬钙

非诺洛芬钙用途

Fenoprofen钙是非甾体类，抗炎化合物，对关节炎有效。

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非诺洛芬钙名称

[ CAS 号 ]:
34597-40-5

[ 中文名 ]:
非诺洛芬钙

[ 英文名 ]:
Fenoprofen Calcium

[中文别名 ]:

菲诺洛芬钙

[英文别名 ]:

calciumfenoprofen
FENOPROFEN CALCIUM
Fepron
nalfon
calcium methyl-3-phenoxybenzeneacetate
fenoprofen-calcium dihydrate

非诺洛芬钙生物活性

[ 描述 ]:

Fenoprofen钙是非甾体类,抗炎化合物,对关节炎有效。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

COX

[参考文献]

[1]. Takashima-Hirano M, et al. General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression. Chemistry. 2010 Apr 12;16(14):4250-8.

[相关活性小分子]

非诺洛芬钙物理化学性质

[ 密度 ]:
1.183g/cm3

[ 沸点 ]:
381.3ºC at 760mmHg

[ 分子式 ]:
C₁₅H₁₄Ca_0.5O₃

[ 分子量 ]:
262.31

[ 闪点 ]:
141.7ºC

[ PSA ]:
71.06000

[ LogP ]:
7.17980

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

非诺洛芬钙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1678870

CHEMICAL NAME :: Benzeneacetic acid, alpha-methyl-3-phenoxy-, calcium salt, (+-)-

CAS REGISTRY NUMBER :: 34597-40-5

LAST UPDATED :: 199203

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C30-H26-O6.Ca

MOLECULAR WEIGHT :: 522.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 415 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 14,4385,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 686 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Blood - changes in spleen

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 14,4385,1980

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非诺洛芬钙安全信息

[ 危害码 (欧洲) ]:
N