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克利溴铵

克利溴铵用途

Clidinium溴化物是一种抗胆碱能药 (具体为毒蕈碱拮抗剂), 通过减少胃酸, 减缓了肠道蠕动, 而缓解痉挛和腹痛/胃痛症状。

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克利溴铵名称

[ CAS 号 ]:
3485-62-9

[ 中文名 ]:
克利溴铵

[ 英文名 ]:
clidinium bromide

[中文别名 ]:

[英文别名 ]:

MFCD00078996
1-Methyl-3-benziloyloxyquinuclidinium Bromide
Ro 2-3773
clidinium bromide
EINECS 222-471-3
UNII:91ZQW5JF1Z
Clidinium (bromide)

克利溴铵生物活性

[ 描述 ]:

Clidinium溴化物是一种抗胆碱能药 (具体为毒蕈碱拮抗剂), 通过减少胃酸, 减缓了肠道蠕动, 而缓解痉挛和腹痛/胃痛症状。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[相关活性小分子]

克利溴铵物理化学性质

[ 熔点 ]:
240-241°C

[ 分子式 ]:
C₂₂H₂₆BrNO₃

[ 分子量 ]:
432.351

[ 精确质量 ]:
431.109589

[ PSA ]:
46.53000

[ 外观性状 ]:
白色结晶固体

[ 储存条件 ]:
Refrigerator

克利溴铵MSDS

克利溴铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD6125000

CHEMICAL NAME :: Quinuclidinium, 3-hydroxy-1-methyl-, bromide, benzilate

CAS REGISTRY NUMBER :: 3485-62-9

LAST UPDATED :: 199009

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C22-H26-N-O3.Br

MOLECULAR WEIGHT :: 432.40

WISWESSER LINE NOTATION :: T66 A B CKTJ AOVXQR&R& C &E &10/27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 492 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,284,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,284,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,284,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,284,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,291,1952

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克利溴铵安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
3

[ RTECS号 ]:
VD6125000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

克利溴铵合成路线

克利溴铵上下游产品

克利溴铵上游产品

克利溴铵下游产品

克利溴铵海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

克利溴铵文献

Pharmacologic comparison of selected agonists for the M1 muscarinic receptor in transfected murine fibroblast cells (B82).

J. Pharmacol. Exp. Ther. 256 , 689, (1991)

The radioligand binding and functional properties of 10 muscarinic agonists for the M1 muscarinic receptors were characterized on the murine fibroblast B82 cells, which have been transfected with the ...

Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration techniques.

Drug Test. Anal. 2(9) , 430-5, (2010)

Three multivariate modelling approaches including partial least squares regression (PLS), genetic algorithm-partial least squares regression (GA-PLS), and principal components-artificial neural networ...

Gastrointestinal dysfunction following hemolytic uremic syndrome.

Dig. Dis. Sci. 56(8) , 2241-3, (2011)

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