< 生产厂家 价格 >

氯霉素琥珀酸酯

氯霉素琥珀酸酯用途

琥珀酸氯霉素是氯霉素的一种促发剂,具有血液毒性。琥珀酸氯霉素也是一种抗生素。琥珀酸氯霉素是琥珀酸脱氢酶(SDH)的竞争性底物和抑制剂,这可能是其毒性的原因[1][2][3][4]。
点击显示

氯霉素琥珀酸酯名称

[ CAS 号 ]:
3544-94-3

[ 中文名 ]:
琥珀酸氯霉素

[ 英文名 ]:
Chloramphenicol Succinate

[中文别名 ]:

[英文别名 ]:

氯霉素琥珀酸酯生物活性

[ 描述 ]:

琥珀酸氯霉素是氯霉素的一种促发剂,具有血液毒性。琥珀酸氯霉素也是一种抗生素。琥珀酸氯霉素是琥珀酸脱氢酶(SDH)的竞争性底物和抑制剂,这可能是其毒性的原因[1][2][3][4]。

[ 相关类别 ]:

研究领域 >> 感染
研究领域 >> 代谢疾病
信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9(3):222-38.  

[2]. Ambekar CS, et al. Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Toxicol In Vitro. 2004 Aug;18(4):441-7.  

[3]. Turton JA, et al. Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar Hanover rat. Hum Exp Toxicol. 1999 Sep;18(9):566-76.  

[4]. Lofrano G, et al. Photocatalytic degradation of the antibiotic chloramphenicol and effluent toxicity effects. Ecotoxicol Environ Saf. 2016 Jan;123:65-71.  

氯霉素琥珀酸酯物理化学性质

[ 密度 ]:
1.536g/cm3

[ 沸点 ]:
716.3ºC at 760mmHg

[ 分子式 ]:
C15H16Cl2N2O8

[ 分子量 ]:
423.20

[ 闪点 ]:
387ºC

[ 精确质量 ]:
422.02800

[ PSA ]:
162.24000

[ LogP ]:
2.68820

[ 折射率 ]:
1.589

[ 储存条件 ]:
库房低温通风干燥

氯霉素琥珀酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WM9650000
CHEMICAL NAME :
Succinic acid, alpha-monoester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy- alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide
CAS REGISTRY NUMBER :
3544-94-3
BEILSTEIN REFERENCE NO. :
3228488
LAST UPDATED :
199612
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C15-H16-Cl2-N2-O8
MOLECULAR WEIGHT :
423.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 4,135,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,1405,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,1405,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 4,135,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,21,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 4,135,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,21,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,21,1954 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
750 mg/kg
SEX/DURATION :
female 7-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 213,238,1981
点击显示

氯霉素琥珀酸酯上下游产品

氯霉素琥珀酸酯上游产品

氯霉素琥珀酸酯下游产品

推荐生产厂家/供应商：

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥1295.0/5mg ￥4984.0/25mg ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Chloramphenicol Succinate

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥2368.9/25mg ￥579.9/5mg ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：氯霉素琥珀酸酯

公司名：武汉壹加壹生物科技有限公司

区域：武汉市江夏区

价格：
￥需询单/1kg

联系人：刘经理

产品详情：琥珀酸氯霉素

查看所有供应商请点击：

氯霉素琥珀酸酯供应商

热门化合物

【氯霉素琥珀酸酯】化源网提供氯霉素琥珀酸酯CAS号3544-94-3，氯霉素琥珀酸酯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氯霉素琥珀酸酯上化源网，专业又轻松。>>电脑版：氯霉素琥珀酸酯

标题：氯霉素琥珀酸酯_用途_密度_沸点_CAS号【3544-94-3】_化源网 地址：https://m.chemsrc.com/mip/cas/3544-94-3_182511.html