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2-(4-甲基-1H-咪唑-5-基)乙胺

2-(4-甲基-1H-咪唑-5-基)乙胺用途

4-甲基组胺是组胺4受体(H4R)的强效激动剂。4-甲基组胺具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1][2]。

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2-(4-甲基-1H-咪唑-5-基)乙胺名称

[ CAS 号 ]:
36507-31-0

[ 中文名 ]:
5-(2-氨基乙基)-4-甲基咪唑

[ 英文名 ]:
2-(4-Methyl-1H-imidazol-5-yl)ethanamine

[英文别名 ]:

4-Methylhistamine
4-(2-aminoethyl)-5-methyl-1H-imidazole
2-(5-methyl-1(3)H-imidazol-4-yl)-ethylamine
2-(5-methyl-1H-imidazol-4-yl)ethanamine
5-Methylhistamine
2-(5-methyl-1H-imidazol-4-yl)-ethylamine
5(4)-Methylhistamine
1H-Imidazo-4-ethanamine,5-methyl
2-(5-methyl-4-imidazolyl)ethylamine
IMIDAZOLE,4-(2-AMINOETHYL)-5-METHYL

2-(4-甲基-1H-咪唑-5-基)乙胺生物活性

[ 描述 ]:

4-甲基组胺是组胺4受体(H4R)的强效激动剂。4-甲基组胺具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[参考文献]

[1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.

[2]. Kim CH, et al. Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine. Scand J Immunol. 2016 Jun;83(6):409-17.

2-(4-甲基-1H-咪唑-5-基)乙胺物理化学性质

[ 密度 ]:
1.1g/cm3

[ 沸点 ]:
345ºC at 760mmHg

[ 分子式 ]:
C₆H₁₁N₃

[ 分子量 ]:
125.17

[ 闪点 ]:
189.3ºC

[ 精确质量 ]:
125.09500

[ PSA ]:
54.70000

[ LogP ]:
0.91960

[ 储存条件 ]:
2-8°C

2-(4-甲基-1H-咪唑-5-基)乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3505600

CHEMICAL NAME :: Imidazole, 4-(2-aminoethyl)-5-methyl-

CAS REGISTRY NUMBER :: 36507-31-0

LAST UPDATED :: 198708

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H11-N3

MOLECULAR WEIGHT :: 125.20

WISWESSER LINE NOTATION :: T5M CNJ D2Z E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 100 umol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975

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2-(4-甲基-1H-咪唑-5-基)乙胺安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933290090

2-(4-甲基-1H-咪唑-5-基)乙胺合成路线

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2-(4-甲基-1H-咪唑-5-基)乙胺下游产品

2-(4-甲基-1H-咪唑-5-基)乙胺海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%