2-(4-甲基-1H-咪唑-5-基)乙胺

• 常用名: 2-(4-甲基-1H-咪唑-5-基)乙胺
• 英文名: 2-(4-Methyl-1H-imidazol-5-yl)ethanamine
• CAS号: 36507-31-0
• 分子量: 125.17
• 密度: 1.1g/cm3
• 沸点: 345ºC at 760mmHg
• 分子式: C₆H₁₁N₃
• 熔点: N/A
• 闪点: 189.3ºC

2-(4-甲基-1H-咪唑-5-基)乙胺用途

4-甲基组胺是组胺4受体(H4R)的强效激动剂。4-甲基组胺具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1][2]。

2-(4-甲基-1H-咪唑-5-基)乙胺名称

• 中文名: 5-(2-氨基乙基)-4-甲基咪唑
• 英文名: 4-methylhistamine

2-(4-甲基-1H-咪唑-5-基)乙胺生物活性

• 描述: 4-甲基组胺是组胺4受体(H4R)的强效激动剂。4-甲基组胺具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 参考文献:

  [1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.

  [2]. Kim CH, et al. Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine. Scand J Immunol. 2016 Jun;83(6):409-17.

2-(4-甲基-1H-咪唑-5-基)乙胺物理化学性质

• 密度: 1.1g/cm3
• 沸点: 345ºC at 760mmHg
• 分子式: C₆H₁₁N₃
• 分子量: 125.17
• 闪点: 189.3ºC
• 精确质量: 125.09500
• PSA: 54.70000
• LogP: 0.91960
• InChIKey: UGYXPZQILZRKJJ-UHFFFAOYSA-N
• SMILES: Cc1[nH]cnc1CCN
• 储存条件: 2-8°C

2-(4-甲基-1H-咪唑-5-基)乙胺毒性和生态

2-(4-甲基-1H-咪唑-5-基)乙胺安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2933290090

2-(4-甲基-1H-咪唑-5-基)乙胺海关

• 海关编码: 2933290090
• 中文概述: 2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(4-甲基-1H-咪唑-5-基)乙胺靶点实验

查看更多实验

实验名称：Selectivity ratio for histamine H4 receptor over histamine H3 receptor 来源：ChEMBL 靶标：N/A External Id：CHEMBL1694500

实验名称：Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by C... 来源：ChEMBL 靶标：Histamine H4 receptor External Id：CHEMBL1638851

实验名称：Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by C... 来源：ChEMBL 靶标：Histamine H4 receptor External Id：CHEMBL1638852

实验名称：Selectivity ratio of EC50 for human histamine H4 receptor to EC50 for human histamine... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1638853

实验名称：Selectivity ratio of EC50 for human histamine H4 receptor to EC50 for human histamine... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1638854

实验名称：Selectivity ratio of EC50 for human histamine H4 receptor to EC50 for human histamine... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1638855

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Relative inhibition of [3H]histamine release from pre-loaded slices of rat cerebral c... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL796898

实验名称：Selectivity ratio of EC50 for human histamine H4 receptor to EC50 for mouse histamine... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1638885

实验名称：Human H4 receptor (Histamine receptors) 来源：IUPHAR-DB 靶标：H4 receptor (Histamine receptors) [Homo sapiens] External Id：265_Human

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2-(4-甲基-1H-咪唑-5-基)乙胺英文别名

• 4-Methylhistamine
• 4-(2-aminoethyl)-5-methyl-1H-imidazole
• 2-(5-methyl-1(3)H-imidazol-4-yl)-ethylamine
• 2-(5-methyl-1H-imidazol-4-yl)ethanamine
• 5-Methylhistamine
• 2-(5-methyl-1H-imidazol-4-yl)-ethylamine
• 5(4)-Methylhistamine
• 1H-Imidazo-4-ethanamine,5-methyl
• 2-(5-methyl-4-imidazolyl)ethylamine
• IMIDAZOLE,4-(2-AMINOETHYL)-5-METHYL
• 1H-Imidazole-4-ethanamine,5-methyl
• 2-(5-Methyl-1(3)H-imidazol-4-yl)-aethylamin