菠萝蛋白酶

菠萝蛋白酶用途

茎菠萝蛋白酶(EC 3.4.22.32)是一种半胱氨酸蛋白酶,从菠萝(Ananas comosus)茎中分离出来。茎菠萝蛋白酶是一种主要的菠萝蛋白酶,具有多种纤溶、抗水肿、抗血栓和抗炎活性。茎菠萝蛋白酶具有体内抗肿瘤和抗白血病活性,以及抗转移作用[1][2]。

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菠萝蛋白酶名称

[ CAS 号 ]:
37189-34-7

[ 中文名 ]:
菠萝蛋白酶

[ 英文名 ]:
Ananas comosus

[英文别名 ]:

EINECS 253-387-5
MFCD00081423

菠萝蛋白酶生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[参考文献]

[1]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.

[2]. Báez R, et al. In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Planta Med. 2007 Oct;73(13):1377-83.

菠萝蛋白酶物理化学性质

[ 分子式 ]:
n_.a_.

[ 外观性状 ]:
powder | yellow-brown

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: soluble1.0mg/mL, clear, colorless

菠萝蛋白酶安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H319-H334-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338-P342 + P311

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
36/37/38-42

[ 安全声明 (欧洲) ]:
22-24-26-36/37-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ 海关编码 ]:
35079090

菠萝蛋白酶制备

[制取方法]由菠萝果实及茎（主要利用其外皮）经压榨提取、盐析（或丙酮、乙醇沉淀），再经过分离、干燥而得。或用水提取后再经精制处理而得。

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菠萝蛋白酶文献

Inhibitory effects of bromelain, a cysteine protease derived from pineapple stem (Ananas comosus), on intestinal motility in mice.

Neurogastroenterol. Motil. 23(8) , 745-e331, (2011)

Bromelain (BR) is a cysteine protease with inhibitory effects on intestinal secretion and inflammation. However, its effects on intestinal motility are largely unexplored. Thus, we investigated the ef...

Trifluoroethanol stabilizes the molten globule state and induces non-amyloidic turbidity in stem bromelain near its isoelectric point.

Int. J. Biol. Macromol. 49 , 536-542, (2011)

Stem bromelain (SBM) is a therapeutic protein that has been studied for alkaline denaturation in the intestines, the principal site of its absorption. In this study, we investigated fluorinated alcoho...

Concentration-dependent antagonistic persuasion of SDS and naphthalene derivatives on the fibrillation of stem bromelain.

Arch. Biochem. Biophys. 540(1-2) , 101-16, (2013)

Sodium dodecyl sulfate, a biological membrane mimetic, can be used to study the conversion of globular proteins into amyloid fibrils in vitro. Using multiple approaches, the effect of SDS was examined...

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