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三甲沙林

三甲沙林用途

Trioxsalen是呋喃和补骨脂素衍生物, 与UV-A联用光疗治疗白癜风和手部湿疹, 光敏后产生交联DNA, 这可能会导致细胞程序性死亡。

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三甲沙林名称

[ CAS 号 ]:
3902-71-4

[ 中文名 ]:
4,5‘,8-三甲基]补骨脂素

[ 英文名 ]:
Trioxsalen

[中文别名 ]:

[英文别名 ]:

EINECS 223-459-0
4,2',8-trimethylpsoralen
4,5',8-Trimethylpsoralen
2,5,9-Trimethyl-7H-furo[3,2-g]chromen-7-one
Trisoralen
2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
2,5,9-trimethylfuro[3,2-g]chromen-7-one
Trioxysalenum
Trioxysalene
UNII-Y6UY8OV51T

三甲沙林生物活性

[ 描述 ]:

Trioxsalen是呋喃和补骨脂素衍生物, 与UV-A联用光疗治疗白癜风和手部湿疹, 光敏后产生交联DNA, 这可能会导致细胞程序性死亡。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[相关活性小分子]

三甲沙林物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
389.0±30.0 °C at 760 mmHg

[ 熔点 ]:
229-231ºC(lit.)

[ 分子式 ]:
C₁₄H₁₂O₃

[ 分子量 ]:
228.243

[ 闪点 ]:
189.1±24.6 °C

[ 精确质量 ]:
228.078644

[ PSA ]:
43.35000

[ LogP ]:
3.80

[ 外观性状 ]:
结晶粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.613

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: soluble

三甲沙林MSDS

详细MSDS(安全技术说明书)

三甲沙林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1576000

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one, 2,5,9-trimethyl-

CAS REGISTRY NUMBER :: 3902-71-4

BEILSTEIN REFERENCE NO. :: 0221723

LAST UPDATED :: 199806

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

WISWESSER LINE NOTATION :: T C566 DO LVOJ B1 E1 J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >22 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 3 mg/L

REFERENCE :: BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 20,1431,1981 *** REVIEWS *** IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,357,1986 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,357,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,366,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5360 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

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三甲沙林安全信息

[ 符号 ]:

GHS05, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H351

[ 警示性声明 ]:
P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34;R40

[ 安全声明 (欧洲) ]:
26-36/37/39-45

[ 危险品运输编码 ]:
UN 1759 8

[ WGK德国 ]:
2

[ RTECS号 ]:
LV1576000

[ 海关编码 ]:
2932999099

三甲沙林上下游产品

三甲沙林上游产品

三甲沙林下游产品

三甲沙林海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

三甲沙林文献

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The cohesin complex holds sister chromatids together and prevents premature chromosome segregation until the onset of anaphase. Mcd1 (also known as Scc1), the α-kleisin subunit of cohesin, is a key re...

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.

J. Cell Biol. 208(5) , 563-79, (2015)

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of suble...

Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation.

Bioconjug. Chem. 18(2) , 431-7, (2007)

DNA interstrand cross-links are formed by chemotherapy drugs as well as by products of normal oxidative metabolism. Despite their importance, the pathways of cross-link metabolism are poorly understoo...

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