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3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺

用途

VU0152100是M4 mAChR的变构增强剂，EC50为380 nM。

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名称

[ CAS 号 ]:
409351-28-6

[ 中文名 ]:
3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺

[ 英文名 ]:
VU0152100

[英文别名 ]:

ML108
Kinome_1269
VU0152100

生物活性

[ 描述 ]:

VU0152100是M4 mAChR的变构增强剂,EC50为380 nM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.

[相关活性小分子]

物理化学性质

[ 分子式 ]:
C₁₈H₁₉N₃O₂S

[ 分子量 ]:
341.42700

[ 精确质量 ]:
341.12000

[ PSA ]:
105.48000

[ LogP ]:
4.40600

[ 储存条件 ]:
2-8℃

安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

文献

Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors.

J. Neurosci. Res. 93 , 1592-9, (2015)

Dopamine and acetylcholine are two principal transmitters in the striatum and are usually balanced to modulate local neural activity and to maintain striatal homeostasis. This study investigates the r...

Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber).

J. Comp. Physiol. A. Neuroethol. Sens. Neural. Behav. Physiol. 202 , 7-15, (2016)

The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M1 and M4. The protein sequence...

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

ACS Chem. Neurosci. 5(10) , 920-42, (2014)

Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neu...

更多文献

3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺

用途

名称

生物活性

物理化学性质

安全信息

文献

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