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Benzyl selenocyanate

Benzyl selenocyanate用途

Benzyl selenocyanate 是一种化学预防剂,用于动物模型中各种化学诱导肿瘤的启动和启动后阶段。Benzyl selenocyanate 是一种 Mtase 抑制剂,其 IC50 值为 8.4 µM 。

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Benzyl selenocyanate名称

[ CAS 号 ]:
4671-93-6

[ 中文名 ]:
硒氰酸苄酯

[ 英文名 ]:
Benzyl selenocyanate

[英文别名 ]:

Selenocyansaeure-benzylester
Benzylselenocyanat
C8H7NSe
benzylselenocyanate
phenylmethaneselenenyl cyanide
Selenocyanic acid,benzyl ester

Benzyl selenocyanate生物活性

[ 描述 ]:

Benzyl selenocyanate 是一种化学预防剂,用于动物模型中各种化学诱导肿瘤的启动和启动后阶段。Benzyl selenocyanate 是一种 Mtase 抑制剂,其 IC50 值为 8.4 µM 。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 表观遗传学 >> DNA甲基转移酶

[ 靶点 ]

Mtase[1]

[体外研究]

硒氰酸苄酯以浓度依赖性方式抑制DNA(胞嘧啶-5)-甲基转移酶(Mtase)的活性[1]。

[参考文献]

[1]. E S Fiala, er al. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis. 1998 Apr;19(4):597-604.

Benzyl selenocyanate物理化学性质

[ 沸点 ]:
276.7ºC at 760 mmHg

[ 分子式 ]:
C₈H₇NSe

[ 分子量 ]:
196.10800

[ 闪点 ]:
121.2ºC

[ 精确质量 ]:
196.97400

[ PSA ]:
23.79000

[ LogP ]:
1.63828

[ 储存条件 ]:
2-8°C，密封，干燥

Benzyl selenocyanate毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT0795000

CHEMICAL NAME :: Selenocyanic acid, benzyl ester

CAS REGISTRY NUMBER :: 4671-93-6

BEILSTEIN REFERENCE NO. :: 1932614

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H7-N-Se

MOLECULAR WEIGHT :: 196.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 98500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45500 ug/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 227 nmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 232,227,1990

Benzyl selenocyanate

Benzyl selenocyanate用途

Benzyl selenocyanate名称

Benzyl selenocyanate生物活性

Benzyl selenocyanate物理化学性质

Benzyl selenocyanate毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Benzyl selenocyanate合成路线

详细合成路线

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