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蟾毒它灵, 蟾蜍他灵

蟾毒它灵, 蟾蜍他灵用途

蟾蜍他灵(Bufotalin)是由蟾蜍种群分泌的蟾酥甾甾体激素,心脏糖苷类似物,被报道具有抗癌活性。
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蟾毒它灵, 蟾蜍他灵名称

[ CAS 号 ]:
471-95-4

[ 中文名 ]:
蟾毒它灵

[ 英文名 ]:
Bufotaline

[中文别名 ]:

[英文别名 ]:

蟾毒它灵, 蟾蜍他灵生物活性

[ 描述 ]:

蟾蜍他灵(Bufotalin)是由蟾蜍种群分泌的蟾酥甾甾体激素,心脏糖苷类似物,被报道具有抗癌活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
天然产物 >> 类固醇
研究领域 >> 癌症

[参考文献]

[1]. Zhu YR, et al. Bufotalin-induced apoptosis in osteoblastoma cells is associated with endoplasmic reticulum stress activation. Biochem Biophys Res Commun. 2014 Aug 15;451(1):112-8.

[2]. Zhang DM, et al. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. Eur J Pharmacol. 2012 Oct 5;692(1-3):19-28.

[3]. Waiwut P, et al. Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways. Int J Oncol. 2012 Jan;40(1):203-8.

[4]. Su CL, et al. Involvement of caspases and apoptosis-inducing factor in bufotalin-induced apoptosis of Hep 3B cells. J Agric Food Chem. 2009 Jan 14;57(1):55-61.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

蟾毒它灵, 蟾蜍他灵物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
591.7±50.0 °C at 760 mmHg

[ 熔点 ]:
223°C (rough estimate)

[ 分子式 ]:
C26H36O6

[ 分子量 ]:
444.560

[ 闪点 ]:
195.8±23.6 °C

[ 精确质量 ]:
444.251190

[ PSA ]:
96.97000

[ LogP ]:
2.54

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±3.8 mmHg at 25°C

[ 折射率 ]:
1.587

[ 储存条件 ]:
库房通风低温干燥

蟾毒它灵, 蟾蜍他灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EI3150000
CHEMICAL NAME :
5-beta-Bufa-20,22-dienolide, 3-beta,14,16-beta-trihydroxy-, 16-acetate
CAS REGISTRY NUMBER :
471-95-4
LAST UPDATED :
199109
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C26-H36-O6
MOLECULAR WEIGHT :
444.62
WISWESSER LINE NOTATION :
L E5 B666TJ A1 E1 GOV1 IQ OQ F- ET6OVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 4,331,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4130 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1131 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
980 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 152,571,1958
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
360 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 152,571,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
136 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 74,223,1942
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
130 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
1200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 86,138,1920
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蟾毒它灵, 蟾蜍他灵安全信息

[ 危险品运输编码 ]:
UN 3172

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29329990

推荐生产厂家/供应商：

公司名：云南西力生物技术股份有限公司

区域：昆明市盘龙区

价格：
￥需询单/10mg

联系人：郑雪平

产品详情：蟾毒它灵

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥1178.0/20mg

联系人：刘佳

产品详情：蟾毒它灵

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥1100.0/1g

联系人：李先生

产品详情：蟾蜍他灵；蟾蜍皂素

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥867.0/5mg ￥1471.0/10mg

联系人：夏言

产品详情：[Perfemiker]蟾蜍他灵,99%

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥3501.9/25mg ￥804.9/5mg ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：Bufotaline

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