中草酸

中草酸用途

Mesoxalate (Ketomalonic acid) 是一种二羧酸和酮酸,可阻断 HIV-1 逆转录酶,IC50 值为 2.2 μM。

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中草酸名称

[ CAS 号 ]:
473-90-5

[ 中文名 ]:
中草酸

[ 英文名 ]:
Oxomalonic acid

[中文别名 ]:

氧代丙二酸

[英文别名 ]:

MESOXALIC ACID
2-ketomalonic acid
Mesoxalate
Oxopropanedioic acid
2-Oxomalonsaeure
Ketomalonic acid
2-Oxomalonic acid
Oxomalonic acid
dicarboxylic ketone
2-oxopropanedioic acid

中草酸生物活性

[ 描述 ]:

Mesoxalate (Ketomalonic acid) 是一种二羧酸和酮酸,可阻断 HIV-1 逆转录酶,IC50 值为 2.2 μM。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

[参考文献]

[1]. Jean A Bernatchez, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16;290(3):1474-84.

[2]. W R Davis, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91.

中草酸物理化学性质

[ 密度 ]:
1.832g/cm3

[ 沸点 ]:
405.2ºC at 760mmHg

[ 分子式 ]:
C₃H₂O₅

[ 分子量 ]:
118.04500

[ 闪点 ]:
213ºC

[ 精确质量 ]:
117.99000

[ PSA ]:
91.67000

[ 蒸汽压 ]:
1.06E-07mmHg at 25°C

[ 折射率 ]:
1.504

中草酸MSDS

中草酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OX7480000

CHEMICAL NAME :: Mesoxalic acid

CAS REGISTRY NUMBER :: 473-90-5

BEILSTEIN REFERENCE NO. :: 1754123

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C3-H2-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 81,1225,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 81,1225,1961

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中草酸安全信息

[ 海关编码 ]:
2918300090

中草酸合成路线

中草酸上下游产品

中草酸上游产品

中草酸下游产品

中草酸海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

中草酸