alpha-菠菜甾醇

alpha-菠菜甾醇用途

α-Spinasterol 从 Spinacia oleracea 分离,具有抗菌活性。α-Spinasterol 是一种瞬时受体电位香草酸1 ( TRPV1) 拮抗剂,具有抗炎,抗抑郁,抗氧化和抗伤害作用。α-Spinasterol 抑制 COX-1 和 COX-2 活性,IC50 值分别为 16.17 μM 和 7.76 μM。

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alpha-菠菜甾醇名称

[ CAS 号 ]:
481-18-5

[ 中文名 ]:
a-波菜甾醇

[ 英文名 ]:
alpha-Spinasterol

[中文别名 ]:

[英文别名 ]:

a-Spinasterin
Bessisterol
UNII:0LG993QX1A
Spinasterol
(3b,5a,22E)-Stigmasta-7,22-dien-3-ol
Alpha-Spinasterol
spinasta-7,22-dien-3-ol
Hitodesterol
Chondrillasterol
a-Spinasterol

alpha-菠菜甾醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 感染

信号通路 >> 免疫及炎症 >> COX

研究领域 >> 神经疾病

[ 靶点 ]

COX-1:16.17 μM (IC50)

COX-2:7.76 μM (IC50)

TRPV1

[参考文献]

[1]. Brusco I, et al. α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice. Br J Pharmacol. 2017 Dec;174(23):4247-4262.

[2]. Yang X, et al. A novel method for synthesis of α-spinasterol and its antibacterial activities in combination with ceftiofur. Fitoterapia. 2017 Jun;119:12-19.

alpha-菠菜甾醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
500.0±44.0 °C at 760 mmHg

[ 熔点 ]:
168-169°

[ 分子式 ]:
C₂₉H₄₈O

[ 分子量 ]:
412.691

[ 闪点 ]:
219.1±20.7 °C

[ 精确质量 ]:
412.370514

[ PSA ]:
20.23000

[ LogP ]:
10.13

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.531

[ 储存条件 ]:
2-8℃

alpha-菠菜甾醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WJ2480000

CHEMICAL NAME :: 5-alpha-Stigmasta-7,22-dien-3-beta-ol, (E)-

CAS REGISTRY NUMBER :: 481-18-5

LAST UPDATED :: 198608

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H48-O

MOLECULAR WEIGHT :: 412.77

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 479 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 20,257,1985