Hemokinin 1, human

Hemokinin 1, human用途

Hemokinin 1, human 是选择性的速激肽神经激肽 1 (NK1) 受体完全激动剂。Hemokinin 1, human 也是 NK2 和 NK3 受体的完全激动剂。Hemokinin 1, human 可以产生非阿片样物质的镇痛作用。

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Hemokinin 1, human名称

[ CAS 号 ]:
491851-53-7

[ 中文名 ]:
血激酶1(人类)

[ 英文名 ]:
Hemokinin 1 (human) trifluoroacetate salt

[英文别名 ]:

h-thr-gly-lys-ala-ser-gln-phe-phe-gly-leu-met-nh2
thr-gly-lys-ala-ser-gln-phe-phe-gly-leu-met-nh2
hhk-1

Hemokinin 1, human生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 神经激肽受体

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体

[参考文献]

[1]. Cai-Yun Fu, et al. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS One

[2]. Francesca Bellucci, et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol. 2002 Jan;135(1):266-74.

Hemokinin 1, human物理化学性质

[ 密度 ]:
1.282 g/cm3

[ 沸点 ]:
1669.168ºC at 760 mmHg

[ 分子式 ]:
C₅₄H₈₄N₁₄O₁₄S

[ 分子量 ]:
1184.39000

[ 闪点 ]:
963.278ºC

[ 精确质量 ]:
1183.59000

[ PSA ]:
480.99000

[ LogP ]:
1.08700

Hemokinin 1, humanMSDS

详细MSDS(安全技术说明书)

Hemokinin 1, human安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Hemokinin 1, human文献

Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils.

Neuropharmacology 45(2) , 242-50, (2003)

Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological functions are not fully understood. To date, a unique receptor for HK-1 has not been identified. Recent studies sug...

T-cell developmental blockage by tachykinin antagonists and the role of hemokinin 1 in T lymphopoiesis.

Blood 102(6) , 2165-72, (2003)

Hemokinin 1 (HK-1) is a new member of the tachykinin peptide family that is expressed in hematopoietic cells. Recent reports studying mouse, rat, and human orthologs of HK-1 demonstrate a broader dist...

Characterization of the endokinins: human tachykinins with cardiovascular activity.

Proc. Natl. Acad. Sci. U. S. A. 100 , 6245-6250, (2003)

We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expr...

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