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(+)-鹰爪豆碱

(+)-鹰爪豆碱用途

(+)-Sparteine 是一种天然生物碱,作为一种神经节阻滞剂。在神经细胞中,(+)-Sparteine 竞争性地抑制烟碱型乙酰胆碱受体 (nACh receptor) 活性。

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(+)-鹰爪豆碱名称

[ CAS 号 ]:
492-08-0

[ 中文名 ]:
鹰爪豆碱

[ 英文名 ]:
Pachycarpine

[中文别名 ]:

[英文别名 ]:

Sparteine, (+)-Isomer
lupinidine
sparteine
Pachycarpine
(7α,9α)-Sparteine

(+)-鹰爪豆碱生物活性

[ 描述 ]:

(+)-Sparteine 是一种天然生物碱,作为一种神经节阻滞剂。在神经细胞中,(+)-Sparteine 竞争性地抑制烟碱型乙酰胆碱受体 (nACh receptor) 活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

天然产物 >> 生物碱

研究领域 >> 神经疾病

[ 靶点 ]

AChR[1]

[体外研究]

(+)- Sparteine(2μM)以与电压无关的方式降低由烟碱AChR激活引起的ACh感应电流。 (+)- Sparteine(5,10μM)降低兴奋性突触后电流(EPSC)的幅度和EPSC衰减的时间常数[1]。

[参考文献]

[1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. Mol Pharmacol. 1991 Aug;40(2):180-5.

[相关活性小分子]

(+)-鹰爪豆碱物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
340.9±10.0 °C at 760 mmHg

[ 熔点 ]:
201ºC

[ 分子式 ]:
C₁₅H₂₆N₂

[ 分子量 ]:
234.380

[ 闪点 ]:
148.3±6.8 °C

[ 精确质量 ]:
234.209595

[ PSA ]:
6.48000

[ LogP ]:
3.21

[ 外观性状 ]:
液体;Colorless to Light orange to Yellow clear liquid

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.570

[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免空气,加热

[ 水溶解性 ]:
微溶：乙醇

(+)-鹰爪豆碱MSDS

详细MSDS(安全技术说明书)

(+)-鹰爪豆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT0620000

CHEMICAL NAME :: Pachycarpine

CAS REGISTRY NUMBER :: 492-08-0

BEILSTEIN REFERENCE NO. :: 3540601

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H26-N2

MOLECULAR WEIGHT :: 234.43

WISWESSER LINE NOTATION :: T C66 K66 A HN PNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89100 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SHIYDO Shaanxi Xinyiyao. Shaanxi New Medical. (Shaanxi Renmin Chubanshe, Xi'an, Shaanxi, Peop. Rep. China) V.1- 1972- Volume(issue)/page/year: 11(6),53,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 21(5),46,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 32ZCAI "Ganglion-Blocking and Ganglion-Stimulation Agents," Kharkevich, D.A., Moscow, First Moscow Medical Institute, 1967 Volume(issue)/page/year: -,175,1967