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盐酸甲氯芬酯

盐酸甲氯芬酯用途

Meclofenoxate盐酸盐是DMAE和pCPA合成的酯,有刺激记忆和提高认知的活性。

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盐酸甲氯芬酯名称

[ CAS 号 ]:
3685-84-5

[ 中文名 ]:
氯酯醒

[ 英文名 ]:
Centrophenoxine hydrochloride

[中文别名 ]:

[英文别名 ]:

EINECS 222-975-3
MFCD00012533
Clocete
Centrophenoxine hydrochloride
Meclofenoxate Hydrochloride
Meclofenoxate (hydrochloride)

盐酸甲氯芬酯生物活性

[ 描述 ]:

Meclofenoxate盐酸盐是DMAE和pCPA合成的酯,有刺激记忆和提高认知的活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

[参考文献]

[1]. Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24.

[2]. Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31.

[相关活性小分子]

盐酸甲氯芬酯物理化学性质

[ 沸点 ]:
345.9ºC at 760mmHg

[ 熔点 ]:
133-135°C

[ 分子式 ]:
C₁₂H₁₇Cl₂NO₃

[ 分子量 ]:
294.174

[ 精确质量 ]:
293.058563

[ PSA ]:
38.77000

[ LogP ]:
2.62560

[ 外观性状 ]:
白色至米白色固体

[ 储存条件 ]:
−20°C

盐酸甲氯芬酯MSDS

详细MSDS(安全技术说明书)

盐酸甲氯芬酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG0440000

CHEMICAL NAME :: Acetic acid, (p-chlorophenoxy)-, 2-dimethylaminoethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 3685-84-5

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H16-Cl-N-O3.Cl-H

MOLECULAR WEIGHT :: 294.20

WISWESSER LINE NOTATION :: GR DO1VO2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 865 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963- Volume(issue)/page/year: 16(2),59,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 153,1914,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,814,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,814,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #398M

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 153,1914,1959

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盐酸甲氯芬酯安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36

[ RTECS号 ]:
AG0440000

[ 海关编码 ]:
2922509090

盐酸甲氯芬酯合成路线

详细合成路线

盐酸甲氯芬酯上下游产品

盐酸甲氯芬酯上游产品

盐酸甲氯芬酯下游产品

盐酸甲氯芬酯海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%