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赖氨加压素

赖氨加压素用途

Lysipressin 是一个从猪身上发现的抗利尿激素, 能够诱发兔膀胱平滑肌的收缩,激活腺苷酸环化酶。

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赖氨加压素名称

[ CAS 号 ]:
50-57-7

[ 中文名 ]:
赖氨加压素

[ 英文名 ]:
[Lys8]-Vasopressin TFA

[中文别名 ]:

[英文别名 ]:

EINECS 200-050-5
syntopressin
postacton
Lysipressin Acetate
CYFQNCPKG-NH2
LVP
[Lys8]-vasopressin
LYSPRESSIN
lypressin
8-lysine-vasopressin

赖氨加压素生物活性

[ 描述 ]:

Lysipressin 是一个从猪身上发现的抗利尿激素, 能够诱发兔膀胱平滑肌的收缩,激活腺苷酸环化酶。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

多肽产品

[参考文献]

[1]. Gorbulev V et al. Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line. Eur J Biochem. 1993 Jul 1;215(1):1-7.

[2]. Crankshaw D et al. [Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle.Eur J Pharmacol. 1989 Dec 7;173(2-3):183-8.

[相关活性小分子]

赖氨加压素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1610.4±65.0 °C at 760 mmHg

[ 分子式 ]:
C₄₆H₆₅N₁₃O₁₂S₂

[ 分子量 ]:
1056.218

[ 闪点 ]:
927.7±34.3 °C

[ 精确质量 ]:
1055.431763

[ PSA ]:
476.15000

[ LogP ]:
-5.74

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.581

[ 储存条件 ]:
−20°C

赖氨加压素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YW8659000

CHEMICAL NAME :: Vasopressin, 8-L-lysine-

CAS REGISTRY NUMBER :: 50-57-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C46-H65-N13-O12-S2

MOLECULAR WEIGHT :: 1056.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 5 iu/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 17,419,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraarterial

DOSE :: 0.25 iu/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 17,419,1968

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赖氨加压素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H332

[ 警示性声明 ]:
P261

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YW8659000

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赖氨加压素文献

Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure.

PLoS ONE 8(1) , e52683, (2013)

Only a limited proportion of patients needing pharmacological control of portal hypertension are hemodynamic responders to propranolol. Here we analyzed the effects of zolmitriptan on portal pressure ...

Effects of terlipressin on microcirculation of small bowel mesentery in rats with endotoxic shock

J. Surg. Res. 188(2) , 503-9, (2014)

Background Septic shock is still related to unacceptably high morbidity and mortality. Microcirculatory alteration has been demonstrated to be one important reason associated with this evolution. Vaso...

Terlipressin resolves ascites of cirrhotic rats through downregulation of aquaporin 2.

J. Int. Med. Res. 40(5) , 1735-44, (2012)

To investigate the presence of aquaporin (AQP) 1 and AQP2 in kidneys of cirrhotic rats with ascites, and to determine the effect of terlipressin on AQP1 and AQP2 levels and its therapeutic efficacy in...

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