< 生产厂家 价格 >

L-苯丙氨酸

L-苯丙氨酸用途

L-Phenylalanine是_alpha_2_delta_钙离子通道拮抗剂,Ki为980 nM。
点击显示

L-苯丙氨酸名称

[ CAS 号 ]:
63-91-2

[ 中文名 ]:
L-苯丙氨酸

[ 英文名 ]:
L-Phenylalanine

[中文别名 ]:

[英文别名 ]:

L-苯丙氨酸生物活性

[ 描述 ]:

L-Phenylalanine是_alpha_2_delta_钙离子通道拮抗剂,Ki为980 nM。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道
研究领域 >> 代谢疾病
天然产物 >> 苯丙酸类

[参考文献]

[1]. Mortell, K.H., et al., Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett, 2006. 16(5): p. 1138-41.

[2]. Glushakov, A.V., et al., Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry, 2002. 7(4): p. 359-67.

[3]. Glushakov, A.V., et al., L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res, 2003. 72(1): p. 116-24.

[4]. Glushakov, A.V., et al., Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain, 2005. 128(Pt 2): p. 300-7.

[5]. Moller, H.E., et al., Brain imaging and proton magnetic resonance spectroscopy in patients with phenylketonuria. Pediatrics, 2003. 112(6 Pt 2): p. 1580-3.


[相关活性小分子]

硫酸新霉素 | 硝苯地平 | 氯化乙酰胆碱； 乙酰氯化胆碱 | 离子霉素 | (S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯 | 尼莫地平 | 米贝拉地尔 | 左乙拉西坦 | CDN1163 | 丹曲林钠 | 毒胡萝卜素 | 氟芬那酸 | ABT-639 | N-(2,6-二甲基苯基)-2-(4-(2-羟基-3-(2-甲氧基苯氧基)-丙基)哌嗪-1-基)乙酰胺 二盐酸盐 | 色甘酸钠

L-苯丙氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
307.5±30.0 °C at 760 mmHg

[ 熔点 ]:
270-275ºC (dec.)(lit.)

[ 分子式 ]:
C9H11NO2

[ 分子量 ]:
165.189

[ 闪点 ]:
139.8±24.6 °C

[ 精确质量 ]:
165.078979

[ PSA ]:
63.32000

[ LogP ]:
1.11

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.576

[ 储存条件 ]:
室温

L-苯丙氨酸MSDS

详细MSDS(安全技术说明书)

L-苯丙氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY7535000
CHEMICAL NAME :
Alanine, phenyl-, L-
CAS REGISTRY NUMBER :
63-91-2
LAST UPDATED :
199706
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C9-H11-N-O2
MOLECULAR WEIGHT :
165.21
WISWESSER LINE NOTATION :
QVYZ1R -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5287 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1322 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
276 gm/kg/13W-C
TOXIC EFFECTS :
Behavioral - alteration of operant conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
220 gm/kg
SEX/DURATION :
male 2 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
160 gm/kg
SEX/DURATION :
male 2 week(s) pre-mating female 2 week(s) pre-mating - 8 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
192 gm/kg
SEX/DURATION :
male 2 week(s) pre-mating female 2 week(s) pre-mating - 15 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
21750 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 gm/kg
SEX/DURATION :
female 10-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
7930 mg/kg
SEX/DURATION :
female 8-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1980 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2640 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
6048 mg/kg
SEX/DURATION :
female 8-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
30 mg/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
33600 mg/kg
SEX/DURATION :
female 1-24 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5534 No. of Facilities: 792 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 19901 (estimated) No. of Female Employees: 14903 (estimated)
点击显示

L-苯丙氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
22-24/25-37/39-45-36/37/39-27-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AY7535000

[ 海关编码 ]:
29224995

L-苯丙氨酸合成路线

详细合成路线

L-苯丙氨酸上下游产品

L-苯丙氨酸上游产品

L-苯丙氨酸下游产品

L-苯丙氨酸制备

1.合成法制备苯丙氨酸的收率低，通常从天然产物中提取。将脱脂大豆用盐酸水解后，除去酸性氨基酸，用活性炭或脱色树脂吸附苯丙氨酸和酪氨酸。然后，用溶剂将苯丙氨酸溶出、分离。也可采用先把水解液中的苯丙氨酸转变为2,5-二溴苯磺酸盐，然后利用溶解度的差异，从亮氨酸、精氨酸等氨基酸中分离出来的方法。

2.将脱脂大豆用盐酸水解后，除去酸性氨基酸，用活性炭或脱色树脂吸附苯丙氨酸和酪氨酸。再用溶剂将苯丙氨酸溶出、分离即可。

3.直接发酵法

4. 烟草：BU，22；FC，21。
点击显示

L-苯丙氨酸海关

[ 海关编码 ]: 29224995

L-苯丙氨酸文献

Assessment of protein modifications in liver of rats under chronic treatment with paracetamol (acetaminophen) using two complementary mass spectrometry-based metabolomic approaches.

J. Proteomics 120 , 194-203, (2015)

Liver protein can be altered under paracetamol (APAP) treatment. APAP-protein adducts and other protein modifications (oxidation/nitration, expression) play a role in hepatotoxicity induced by acute o...

Enhanced Indirect Photochemical Transformation of Histidine and Histamine through Association with Chromophoric Dissolved Organic Matter.

Environ. Sci. Technol. 49 , 5511-9, (2015)

Photochemical transformations greatly affect the stability and fate of amino acids (AAs) in sunlit aquatic ecosystems. Whereas the direct phototransformation of dissolved AAs is well investigated, the...

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

J. Agric. Food Chem. 63 , 5670-81, (2015)

In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effec...


更多文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：吉尔生化（上海）有限公司

区域：上海市闵行区

价格：
$需询单/1kg

联系人：杨经理

产品详情：H-Phe-OH

公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：L-苯丙氨酸

公司名：云南西力生物技术股份有限公司

区域：昆明市盘龙区

价格：
￥需询单/50mg

联系人：郑雪平

产品详情：L-苯丙氨酸

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥158.0/200mg ￥338.0/1kg ￥198.0/500g ￥98.0/100g

联系人：刘佳

产品详情：L-苯丙氨酸

公司名：南京肽业生物科技有限公司

区域：南京市六合区

价格：
￥需询单/10g ￥需询单/100g ￥需询单/1kg ￥需询单/10kg

联系人：范经理

产品详情：H-Phe-OH

查看所有供应商请点击：

L-苯丙氨酸供应商

相关化合物

【L-苯丙氨酸】化源网提供L-苯丙氨酸CAS号63-91-2，L-苯丙氨酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询L-苯丙氨酸上化源网，专业又轻松。>>电脑版：L-苯丙氨酸

标题：L-苯丙氨酸_MSDS_用途_密度_L-苯丙氨酸CAS号【63-91-2】_化源网 地址：https://m.chemsrc.com/mip/cas/63-91-2_960340.html