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汉黄芩苷

汉黄芩苷用途

Wogonoside 是从黄芩中分离得到的一种黄酮类苷化合物,具有抗炎作用。Wogonoside 通过调节 MAPK-mTOR 通路诱导乳腺癌细胞的自噬。

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汉黄芩苷名称

[ CAS 号 ]:
51059-44-0

[ 中文名 ]:
汉黄芩苷

[ 英文名 ]:
Wogonoside

[中文别名 ]:

汉黄芩甙

[英文别名 ]:

Oroxindin
Wogonin 7-β-D-glucuronide
wogonin 7-O-glucuronoside
wogonin 7-O-β-D-glucuronide
Wogonin-7-O-|A-D-glucuronide
Wogonoside
Wogonin 7-O-glucuronide
Glychionide B
5,7-dihydroxy-8-methoxyflavone 7-O-β-D-glucuronide

汉黄芩苷生物活性

[ 描述 ]:

Wogonoside 是从黄芩中分离得到的一种黄酮类苷化合物,具有抗炎作用。Wogonoside 通过调节 MAPK-mTOR 通路诱导乳腺癌细胞的自噬。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 自噬 >> 自噬

研究领域 >> 炎症/免疫

[参考文献]

[1]. Yang YZ, et al. Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 2013 Jun 21;148(1):271-6.

[2]. Sun Y, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013 Jan;51:53-60.

汉黄芩苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
869.0±65.0 °C at 760 mmHg

[ 熔点 ]:
226-227ºC

[ 分子式 ]:
C₂₂H₂₀O₁₁

[ 分子量 ]:
460.388

[ 闪点 ]:
304.0±27.8 °C

[ 精确质量 ]:
460.100555

[ PSA ]:
176.12000

[ LogP ]:
1.42

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.685

[ 储存条件 ]:
?20°C

汉黄芩苷MSDS

详细MSDS(安全技术说明书)

汉黄芩苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

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汉黄芩苷文献

Extraction and Bioactivity Analysis of Major Flavones Compounds from Scutellaria baicalensis Using In Vitro Assay and Online Screening HPLC-ABTS System.

J. Anal. Methods Chem. 2014 , 563702, (2014)

The extraction efficiency of a number of solvent compositions for the improvement of bioactive compounds yield from S. baicalensis has been investigated. Also, free radical scavengers in the glycoside...

Wogonoside induces autophagy-related apoptosis in human glioblastoma cells.

Oncol. Rep. 32(3) , 1179-87, (2014)

Wogonoside, a bioactive flavonoid extracted from the root of Scutellaria baicalensis Georgi, has shown preclinical anticancer efficacy in various cancer models. However, the effects of wogonoside on g...

Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf).

J. Chromatogr. Sci. 53 , 1140-6, (2015)

A novel free radical reaction combined with high-performance LC-photodiode array-ESI-MS/MS screening method was developed for the detection and identification of natural antioxidants from whole Scutel...

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