大黄素甲醚

Physcion (Parietin) 是从中药大黄中得到的蒽醌类物质,为 6-磷酸葡萄糖酸脱氢酶 (6-phosphogluconate dehydrogenase) 抑制剂,IC50 和 Kd 值分别为 38.5 μM 和 26.0 μM。Physcion (Parietin) 具有通便、保肝、抗炎、抗菌、抗增殖、抗肿瘤作用。

[ 描述 ]:

[ 相关类别 ]:

[ 靶点 ]

[参考文献]

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
560.5±50.0 °C at 760 mmHg

[ 熔点 ]:
196-206°C

[ 分子式 ]:
C₁₆H₁₂O₅

[ 分子量 ]:
284.26

[ 闪点 ]:
215.4±23.6 °C

[ 精确质量 ]:
284.068481

[ PSA ]:
83.83000

[ LogP ]:
5.20

[ 外观性状 ]:
固体;White to Yellow to Orange powder to crystal

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.678

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

CB6720000

CHEMICAL NAME :

Anthraquinone, 1,8-dihydroxy-3-methoxy-6-methyl-

CAS REGISTRY NUMBER :

521-61-9

BEILSTEIN REFERENCE NO. :

1915778

LAST UPDATED :

199612

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C16-H12-O5

MOLECULAR WEIGHT :

284.28

WISWESSER LINE NOTATION :

L C666 BV IVJ DQ FO1 LO1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

10 mg/kg

TOXIC EFFECTS :

Gastrointestinal - other changes

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

100 ug/plate

REFERENCE :

JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 27,1342,1979

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB6720000

[ 海关编码 ]:
2914699010

详细合成路线

大黄素甲醚上游产品

大黄素甲醚下游产品

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 88-93, (2015)

Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two ...

Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.

Bioorg. Med. Chem. Lett. 18 , 4106-9, (2008)

As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction-oxidation potentials of methylated emodin deriva...

Activity-guided chemo toxic profiling of Cassia occidentalis (CO) seeds: detection of toxic compounds in body fluids of CO-exposed patients and experimental rats.

Chem. Res. Toxicol. 28 , 1120-32, (2015)

Our prior studies have shown an association between the deaths of children and consumption of Cassia occidentalis (CO) seeds. However, the chemicals responsible for the CO poisoning are not known. The...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：大黄素甲醚

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公司名：云南西力生物技术股份有限公司

区域：昆明市盘龙区

价格：
￥需询单/5mg

联系人：郑雪平

产品详情：大黄素甲醚

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥198.0/20mg

联系人：刘佳

产品详情：大黄素甲醚

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Rheochrysidin (Physcione)

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥1760.0/1g ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：大黄素甲醚

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