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普林贝瑞

普林贝瑞用途

Prinaberel(ERB-041)是雌激素受体ERbeta选择高效激动剂。

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普林贝瑞名称

[ CAS 号 ]:
524684-52-4

[ 中文名 ]:
普林贝瑞

[ 英文名 ]:
Prinaberel

[中文别名 ]:

[英文别名 ]:

BIDD:ER0139
SDZ 205-557 hydrochloride
UNII-A9C8MNF7CA
1x7b
Prinaberel
ERB 041

普林贝瑞生物活性

[ 描述 ]:

Prinaberel(ERB-041)是雌激素受体ERbeta选择高效激动剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 癌症

[参考文献]

[1]. Hinsche O, et al. Estrogen receptor β selective agonists reduce invasiveness of triple-negative breast cancer cells. Int J Oncol. 2015 Feb;46(2):878-84.

[2]. Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98.

[3]. Xiu-li W, et al. ERB-041, a selective ER beta agonist, inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-kappaB activation. Mol Immunol. 2009 Jul;46(11-12):2413-8.

[相关活性小分子]

普林贝瑞物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
451.6±45.0 °C at 760 mmHg

[ 熔点 ]:
250-252ºC

[ 分子式 ]:
C₁₅H₁₀FNO₃

[ 分子量 ]:
271.243

[ 闪点 ]:
226.9±28.7 °C

[ 精确质量 ]:
271.064484

[ PSA ]:
66.49000

[ LogP ]:
3.97

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.695

[ 储存条件 ]:
2-8℃

普林贝瑞MSDS

普林贝瑞安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

普林贝瑞合成路线

普林贝瑞文献

Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation.

J. Steroid Biochem. Mol. Biol. 152 , 62-75, (2015)

Genistein has protective effects against prostate cancer (PCa) but whether this protection involves an estrogen receptor (ER) β dependent mechanism has yet to be elucidated. ER-β has a tumor suppresso...

Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists.

PLoS ONE 7 , (2009)

Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be safer for conditions that have been tradit...

Mouse leydig cells with different androgen production potential are resistant to estrogenic stimuli but responsive to bisphenol a which attenuates testosterone metabolism.

PLoS ONE 8 , e71722, (2013)

It is well known that estrogens and estrogen-like endocrine disruptors can suppress steroidogenic gene expression, attenuate androgen production and decrease differentiation of adult Leydig cell linea...

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普林贝瑞

普林贝瑞用途

普林贝瑞名称

普林贝瑞生物活性

普林贝瑞物理化学性质

普林贝瑞MSDS

详细MSDS(安全技术说明书)

普林贝瑞安全信息

普林贝瑞合成路线

详细合成路线

普林贝瑞文献

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