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奎诺二甲基丙烯酸酯

奎诺二甲基丙烯酸酯用途

Troloxa是细胞渗透性和水溶性维生素E类似物,是一种强大的抗氧化剂。

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奎诺二甲基丙烯酸酯名称

[ CAS 号 ]:
53188-07-1

[ 中文名 ]:
奎诺二甲基丙烯酸酯

[ 英文名 ]:
Trolox

[中文别名 ]:

[英文别名 ]:

Trolox
MFCD00006846
EINECS 258-422-8

奎诺二甲基丙烯酸酯生物活性

[ 描述 ]:

Troloxa是细胞渗透性和水溶性维生素E类似物,是一种强大的抗氧化剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[体外研究]

Troloxa已显示可保护哺乳动物细胞免受氧化损伤。 Troloxa在细胞培养研究和左冠状动脉前降支(LAD)闭塞2小时后再灌注4小时的犬模型中有效预防肌细胞坏死[1]。 Trolox可以预防胸腺细胞中氧化应激诱导的细胞凋亡。用Trolox预处理或后处理细胞减少了H2O2诱导的DNA片段化,从而控制水平及以下水平。 [2]。 Trolox是α-生育酚的亲水类似物,据报道在十二烷基硫酸钠胶束和脂质体中比维生素E更好地清除过氧自由基。 Trolox显着延长人体心室肌细胞和肝细胞对黄嘌呤氧化酶加次黄嘌呤产生的氧自由基的存活,并防止暴露于偶氮引发剂的红细胞裂解[3]。

[细胞实验]

在暴露于10μMH2 O 2之前，期间或之后10分钟用Trolox（10mM）处理胸腺细胞。在H2O2暴露之前或之后进行的Trolox孵育在TCM中进行。与H2O2同时施用的Trolox治疗在含有硫酸亚铁的PBS中进行[1]。

[参考文献]

[1]. Mickle DA, et al. Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction. Ann Thorac Surg. 1989 Apr;47(4):553-7.

[2]. Forrest VJ, et al. Oxidative stress-induced apoptosis prevented by Trolox. Free Radic Biol Med. 1994 Jun;16(6):675-84.

[3]. Wu TW, et al. The cytoprotective effect of Trolox demonstrated with three types of human cells. Biochem Cell Biol. 1990 Oct;68(10):1189-94.

[相关活性小分子]

奎诺二甲基丙烯酸酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
450.3±45.0 °C at 760 mmHg

[ 熔点 ]:
187-189ºC(lit.)

[ 分子式 ]:
C₁₄H₁₈O₄

[ 分子量 ]:
250.290

[ 闪点 ]:
171.0±22.2 °C

[ 精确质量 ]:
250.120514

[ PSA ]:
66.76000

[ LogP ]:
3.01

[ 外观性状 ]:
白色至米色结晶粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
可溶于：甲醇

奎诺二甲基丙烯酸酯MSDS

详细MSDS(安全技术说明书)

奎诺二甲基丙烯酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2273000

CHEMICAL NAME :: 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-

CAS REGISTRY NUMBER :: 53188-07-1

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H18-O4

MOLECULAR WEIGHT :: 250.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 52,174,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 52,174,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 52,174,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 52,174,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1930 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 52,174,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 52,174,1975

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奎诺二甲基丙烯酸酯安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ WGK德国 ]:
2

[ RTECS号 ]:
DJ2273000

[ 海关编码 ]:
2932999099

奎诺二甲基丙烯酸酯海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%