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伊索克酸

伊索克酸用途

Isoxepac(HP 549)是一种具有抗炎、镇痛和解热活性的非甾体抗炎药(NSAID)。Isoxepac已在大鼠、兔子、狗、恒河猴等动物中进行了研究[1][2][3]。

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伊索克酸名称

[ CAS 号 ]:
55453-87-7

[ 中文名 ]:
6,11-二氢-11-氧二苯并[b,e]氧杂卓-2-乙酸

[ 英文名 ]:
Isoxepac

[中文别名 ]:

[英文别名 ]:

Isoxepac
MFCD00242952
Artil

伊索克酸生物活性

[ 描述 ]:

Isoxepac(HP 549)是一种具有抗炎、镇痛和解热活性的非甾体抗炎药(NSAID)。Isoxepac已在大鼠、兔子、狗、恒河猴等动物中进行了研究[1][2][3]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. L S Gerlis, et al. Isoxepac in rheumatoid arthritis: a double-blind comparison with aspirin. Rheumatol Rehabil. 1981 Feb 1;20(1):50-3.

[2]. W J Honig, et al. Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial. J Clin Pharmacol. Feb-Mar 1982;22(2-3):82-8.

[3]. H P Illing, et al. Species differences in the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac) in rat, rabbit, dog, rhesus monkey, and man. Drug Metab Dispos. Sep-Oct 1978;6(5):510-7.

伊索克酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
528.2±50.0 °C at 760 mmHg

[ 熔点 ]:
130-132ºC

[ 分子式 ]:
C₁₆H₁₂O₄

[ 分子量 ]:
268.264

[ 闪点 ]:
203.8±23.6 °C

[ 精确质量 ]:
268.073547

[ PSA ]:
63.60000

[ LogP ]:
2.64

[ 外观性状 ]:
淡黄色至灰白的-白色结晶粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.636

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
可溶于：甲醇

伊索克酸MSDS

详细MSDS(安全技术说明书)

伊索克酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ4110000

CHEMICAL NAME :: Dibenz(b,e)oxepin-2-acetic acid, 6,11-dihydro-11-oxo-

CAS REGISTRY NUMBER :: 55453-87-7

BEILSTEIN REFERENCE NO. :: 1320243

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H12-O4

MOLECULAR WEIGHT :: 268.28

WISWESSER LINE NOTATION :: T C676 BV IO JHJ E1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,142,1977

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伊索克酸安全信息

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25-62

[ 安全声明 (欧洲) ]:
36/37-45

[ 海关编码 ]:
2942000000

伊索克酸合成路线

详细合成路线

伊索克酸上下游产品

伊索克酸上游产品

伊索克酸下游产品

伊索克酸海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%