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盐酸奥洛他定

盐酸奥洛他定用途

Olopatadine盐酸盐是组胺受体阻断剂,可作用于过敏性结膜炎。

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盐酸奥洛他定名称

[ CAS 号 ]:
140462-76-6

[ 中文名 ]:
(Z)-11-[3-(二甲基氨基)亚丙基]-6,11-二氢二苯并[b,e]氧杂卓-2-乙酸盐酸盐

[ 英文名 ]:
Olopatadine Hydrochloride

[中文别名 ]:

[英文别名 ]:

AL 4943A
MFCD00875716
Olopatadine hydrochloride
Olopatadine (hydrochloride)

盐酸奥洛他定生物活性

[ 描述 ]:

Olopatadine盐酸盐是组胺受体阻断剂,可作用于过敏性结膜炎。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.

[2]. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug. Jpn J Pharmacol, 2002. 88(4): p. 379-97.

[3]. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400.

[相关活性小分子]

盐酸奥洛他定物理化学性质

[ 密度 ]:
1.221 g/cm3

[ 沸点 ]:
523ºC at 760mmHg

[ 熔点 ]:
242-245ºC

[ 分子式 ]:
C₂₁H₂₄ClNO₃

[ 分子量 ]:
373.873

[ 闪点 ]:
270.1ºC

[ 精确质量 ]:
373.144470

[ PSA ]:
49.77000

[ LogP ]:
4.39150

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
9.65E-13mmHg at 25°C

[ 储存条件 ]:
Refrigerator

盐酸奥洛他定MSDS

盐酸奥洛他定安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H400

[ 警示性声明 ]:
P273-P301 + P310

[ 危害码 (欧洲) ]:
T,N

[ 风险声明 (欧洲) ]:
25-50

[ 安全声明 (欧洲) ]:
45-61

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2932999099

盐酸奥洛他定合成路线

盐酸奥洛他定上下游产品

盐酸奥洛他定上游产品

盐酸奥洛他定下游产品

盐酸奥洛他定海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸奥洛他定文献

Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation.

Eye Contact Lens 40(5) , 283-8, (2014)

To evaluate the use of topical cyclosporine A (CsA) 1% emulsion in the treatment of chronic ocular surface inflammation (OSI).We conducted a retrospective chart review of patients with various forms o...

Histamine suppresses regulatory T cells mediated by TGF-β in murine chronic allergic contact dermatitis.

Exp. Dermatol. 24(4) , 280-4, (2015)

Regulatory T cells (Tregs) suppress effector T cells and ameliorate contact hypersensitivity (CH); however, the role of Tregs in chronic allergic contact dermatitis (CACD) has not been assessed. Repea...

Chromatographic analysis of olopatadine in hydrophilic interaction liquid chromatography.

J. Chromatogr. Sci. 53 , 680-6, (2015)

In this paper, chromatographic analysis of active substance olopatadine hydrochloride, which is used in eye drops as antihistaminic agent, and its impurity E isomer by hydrophilic interaction liquid c...

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