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伊索昔康

伊索昔康用途

Isoxicam 是一种口服有效的非甾体抗炎剂,可用于关节炎的研究。Isoxicam 是一种非选择性的 COX-1 和 COX-2 抑制剂。

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伊索昔康名称

[ CAS 号 ]:
34552-84-6

[ 中文名 ]:
伊索昔康

[ 英文名 ]:
Isoxicam

[中文别名 ]:

[英文别名 ]:

Isoxicam
Isoxicamo [INN-Spanish]
Isoxicamo
EINECS 252-084-5
Isoxicamum [INN-Latin]
Maxicam
UNII:8XU734C4NG
Pacyl (antiinflammatory)
Isoxicamum
UNII-8XU734C4NG

伊索昔康生物活性

[ 描述 ]:

Isoxicam 是一种口服有效的非甾体抗炎剂,可用于关节炎的研究。Isoxicam 是一种非选择性的 COX-1 和 COX-2 抑制剂。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 免疫及炎症 >> COX

[ 靶点 ]

COX-1

COX-2

[参考文献]

[1]. DiPasquale G, et al. The antiinflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide). Agents Actions. 1975 Aug;5(3):256-63.

[2]. Xu S, et al. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 2014 Mar 7;289(10):6799-808.

伊索昔康物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
518.8ºC at 760mmHg

[ 熔点 ]:
265-271℃

[ 分子式 ]:
C₁₄H₁₃N₃O₅S

[ 分子量 ]:
335.335

[ 闪点 ]:
267.5ºC

[ 精确质量 ]:
335.057587

[ PSA ]:
121.12000

[ LogP ]:
1.38

[ 外观性状 ]:
固体

[ 折射率 ]:
1.686

[ 储存条件 ]:
2-8°C，密封，干燥

伊索昔康MSDS

伊索昔康毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL0703000

CHEMICAL NAME :: 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 34552-84-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H13-N3-O5-S

MOLECULAR WEIGHT :: 335.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 7,481,1977

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伊索昔康安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DL0703000

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伊索昔康文献

Effect of some new prostaglandin synthetase inhibitors on the endotoxin induced mortality and biochemical changes in experimental animals.

Res. Commun. Chem. Pathol. Pharmacol. 60(1) , 19-25, (1988)

The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All ...

[The effect of estro-progesterones on the inflammatory episodes of hand arthroses. Apropos of a case].

Rev. Rhum. Mal. Osteoartic. 56(10) , 709-11, (1989)

Controlled-release naproxen compared with isoxicam in patients with osteoarthritis.

Curr. Med. Res. Opin. 11(1) , 28-33, (1988)

The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications w...

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