琥珀酸多西拉敏
琥珀酸多西拉敏用途
琥珀酸多西拉敏名称
[ CAS 号 ]:
562-10-7
[ 中文名 ]:
琥珀酸多西拉敏
[ 英文名 ]:
DOXYLAMINE SUCCINATE
[中文别名 ]:
[英文别名 ]:
- UNII:V9BI9B5YI2
- MFCD00056168
- EINECS 209-228-7
- Doxylamine succinate
- Doxylamine (succinate)
琥珀酸多西拉敏生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
琥珀酸多西拉敏物理化学性质
[ 密度 ]:
1.043g/cm3
[ 沸点 ]:
364.9ºC at 760 mmHg
[ 熔点 ]:
103 - 108ºC
[ 分子式 ]:
C21H28N2O5
[ 分子量 ]:
388.457
[ 闪点 ]:
174.5ºC
[ 精确质量 ]:
388.199829
[ PSA ]:
99.96000
[ LogP ]:
2.85910
[ 外观性状 ]:
白色至淡奶油色粉末
[ 储存条件 ]:
Refrigerator
[ 稳定性 ]:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
[ 水溶解性 ]:
水溶性:完全溶解;可溶于:醇,氯仿;微溶:苯,乙醚
琥珀酸多西拉敏MSDS
琥珀酸多西拉敏毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- US9275000
- CAS REGISTRY NUMBER :
- 562-10-7
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C17-H22-N2-O.C4-H6-O4
- MOLECULAR WEIGHT :
- 388.51
- WISWESSER LINE NOTATION :
- T6NJ BX1&R&O2N1&1 &OV2VO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 62 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 49 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6290 mg/kg/54D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 34155 mg/kg/90D-C
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8100 mg/kg/90D-C
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 2208 mg/kg/13W-I
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - food intake (animal)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 87600 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65520 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 765 mg/kg
- SEX/DURATION :
- female 20-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 1710 mg/kg
- SEX/DURATION :
- female 20-35 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 500 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,131,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84539 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1134 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84539 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)
琥珀酸多西拉敏安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302 + H312 + H332
[ 警示性声明 ]:
P280
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22;R36/37/38
[ 安全声明 (欧洲) ]:
26-36/37
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
US9275000
琥珀酸多西拉敏文献
Toxicol. Sci. 149 , 15-30, (2016)
In utero exposure to certain chemicals can impair embryo development, causing embryonic death, growth retardation, or severe birth defects. Establishment of effective in vitro tests is crucial for ide...
[Nontraumatic rhabdomyolysis due to oral poisoning by doxylamine succinate].Med. Clin. (Barc.) 108(9) , 356, (1997)
Safety assessment of OTC drugs: doxylamine succinate.
Arch. Toxicol. Suppl. 17 , 326-40, (1995)
相关化工产品/化学物质:
相关药品:
推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:N,N-二甲基-2-[1-苯基-1-(2-吡啶)乙氧基]乙胺琥珀酸盐
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Doxylamine succinate
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥406.9/10g
¥69.9/1g
¥254.9/5g
¥812.9/25g
联系人:阿拉丁
产品详情:多西拉敏琥珀酸盐
公司名:西安康诺化工有限公司
区域:西安市雁塔区
价格:
¥需询单/1kg
联系人:高经理
产品详情:琥珀酸多西拉敏
查看所有供应商请点击:
相关化合物
【琥珀酸多西拉敏】化源网提供琥珀酸多西拉敏CAS号562-10-7,琥珀酸多西拉敏MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询琥珀酸多西拉敏上化源网,专业又轻松。>>电脑版:琥珀酸多西拉敏
标题:琥珀酸多西拉敏_MSDS_用途_密度_CAS号【562-10-7】_化源网 地址:https://m.chemsrc.com/mip/cas/562-10-7_1032542.html