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琥珀酸多西拉敏

琥珀酸多西拉敏用途

Doxylamine是第一代抗组胺试剂。
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琥珀酸多西拉敏名称

[ CAS 号 ]:
562-10-7

[ 中文名 ]:
琥珀酸多西拉敏

[ 英文名 ]:
DOXYLAMINE SUCCINATE

[中文别名 ]:

[英文别名 ]:

琥珀酸多西拉敏生物活性

琥珀酸多西拉敏物理化学性质

[ 密度 ]:
1.043g/cm3

[ 沸点 ]:
364.9ºC at 760 mmHg

[ 熔点 ]:
103 - 108ºC

[ 分子式 ]:
C21H28N2O5

[ 分子量 ]:
388.457

[ 闪点 ]:
174.5ºC

[ 精确质量 ]:
388.199829

[ PSA ]:
99.96000

[ LogP ]:
2.85910

[ 外观性状 ]:
白色至淡奶油色粉末

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.

[ 水溶解性 ]:
水溶性:完全溶解;可溶于:醇,氯仿;微溶:苯,乙醚

琥珀酸多西拉敏MSDS

琥珀酸多西拉敏毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US9275000
CAS REGISTRY NUMBER :
562-10-7
LAST UPDATED :
199512
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C17-H22-N2-O.C4-H6-O4
MOLECULAR WEIGHT :
388.51
WISWESSER LINE NOTATION :
T6NJ BX1&R&O2N1&1 &OV2VO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6290 mg/kg/54D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34155 mg/kg/90D-C
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8100 mg/kg/90D-C
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
2208 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - tremor Behavioral - food intake (animal)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
87600 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65520 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
765 mg/kg
SEX/DURATION :
female 20-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
1710 mg/kg
SEX/DURATION :
female 20-35 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,131,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84539 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1134 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84539 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)
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琥珀酸多西拉敏安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
US9275000

琥珀酸多西拉敏文献

Use of In Vitro Morphogenesis of Mouse Embryoid Bodies to Assess Developmental Toxicity of Therapeutic Drugs Contraindicated in Pregnancy.

Toxicol. Sci. 149 , 15-30, (2016)

In utero exposure to certain chemicals can impair embryo development, causing embryonic death, growth retardation, or severe birth defects. Establishment of effective in vitro tests is crucial for ide...

[Nontraumatic rhabdomyolysis due to oral poisoning by doxylamine succinate].

Med. Clin. (Barc.) 108(9) , 356, (1997)

Safety assessment of OTC drugs: doxylamine succinate.

Arch. Toxicol. Suppl. 17 , 326-40, (1995)


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公司名:上海源溪生物科技有限公司

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产品详情:Doxylamine succinate


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥406.9/10g ¥69.9/1g ¥254.9/5g ¥812.9/25g

联系人:阿拉丁

产品详情:多西拉敏琥珀酸盐


公司名:西安康诺化工有限公司

区域:西安市雁塔区

价格:
¥需询单/1kg

联系人:高经理

产品详情:琥珀酸多西拉敏


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【琥珀酸多西拉敏】化源网提供琥珀酸多西拉敏CAS号562-10-7,琥珀酸多西拉敏MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询琥珀酸多西拉敏上化源网,专业又轻松。>>电脑版:琥珀酸多西拉敏

标题:琥珀酸多西拉敏_MSDS_用途_密度_CAS号【562-10-7】_化源网 地址:https://m.chemsrc.com/mip/cas/562-10-7_1032542.html