苦豆碱

苦豆碱用途

Aloperine 是一种在苦参类 (例如苦豆子 Sophora alopecuroides L) 植物中生物碱,其具有抗癌,抗炎和抗病毒特性。Aloperine 被广泛用于治疗过敏性接触性皮炎湿疹和其他皮肤炎症。Aloperine 诱导 HL-60 细胞中诱导凋亡 apoptosis 和自噬 autophagy。

点击显示

苦豆碱名称

[ CAS 号 ]:
56293-29-9

[ 中文名 ]:
苦豆碱

[ 英文名 ]:
Aloperine

[英文别名 ]:

ALOPERIN
ALLOPTERIN
Aloperine,orMosanine

苦豆碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 自噬 >> 自噬

研究领域 >> 炎症/免疫

[体外研究]

Aloperine(1-20 mM; 24小时)使癌细胞中的生长抑制性IC50值在0.04至1.36 mM之间,HL-60,U937,K562,EC109,A549和HepG2细胞中的IC50值分别为0.04,0.27,0.36,1.11,1.18和1.36 mM[1]。Aloperine(1-20 mM; 24小时)诱导细胞凋亡并降低HL-60细胞中bcl-2的表达[1]。Aloperine(20-100 mM; 18小时)诱导HL-60细胞中的自噬和酸性液泡的形成[1]。

[参考文献]

[1]. Lin Z, et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 2011 May;108(5):304-9.

[2]. Yuan XY, et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 2010 Mar 10;629(1-3):147-52.

苦豆碱物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
367.7±37.0 °C at 760 mmHg

[ 熔点 ]:
69 - 71ºC

[ 分子式 ]:
C₁₅H₂₄N₂

[ 分子量 ]:
232.365

[ 闪点 ]:
155.8±17.5 °C

[ 精确质量 ]:
232.193954

[ PSA ]:
15.27000

[ LogP ]:
3.21

[ 外观性状 ]:
黄色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
-20℃

苦豆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RM2979500

CHEMICAL NAME :: Ormosanine, 16,17-didehydro-9-de-2-piperidinyl-, (7-alpha,9-alpha)-

CAS REGISTRY NUMBER :: 56293-29-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H24-N2

MOLECULAR WEIGHT :: 232.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 10,360,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 869 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 18,214,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 154 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 17,170,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

点击显示

苦豆碱安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RM2979500

苦豆碱上下游产品

苦豆碱上游产品

苦豆碱下游产品

苦豆碱文献

Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis.

PLoS ONE 11 , e0149618, (2016)

Porphyromonas gingivalis is a keystone pathogen of periodontitis. One of its bacterial characteristics is the ability to invade various host cells, including nonphagocytic epithelial cells and fibrobl...

Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms.

J. Hematol. Oncol. 8 , 26, (2015)

Aloperine, a natural alkaloid constituent isolated from the herb Sophora alopecuroides displays anti-inflammatory properties in vitro and in vivo. Our group previously demonstrated that aloperine sign...

[Simultaneous determination of 7 alkaloid in herba Sophorae Alopecuroidis by HPLC].

Zhongguo Zhong Yao Za Zhi 36(11) , 1483-6, (2011)

To establish a method for determination of 7 alkaloid in Herba Sophorae Alopecuroidis by HPLC.X-Brige C18 (4.6 mm x 200 mm, 5 microm) column was used with acetonitriles-0.05 mol x L(-1) KH2PO4 solutio...

更多文献

苦豆碱