斯普利特麻一辛

斯普利特麻一辛用途

Splitomicin (Splitomycin) 是一种选择性的 Sir2p 抑制剂。Splitomicin 抑制 Sir2 蛋白的 NAD+ 依赖性 HDAC 活性。Splitomicin 抑制酵母提取物中 HDAC,IC50 为 60 μM。

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斯普利特麻一辛名称

[ CAS 号 ]:
5690-03-9

[ 中文名 ]:
1,2-二氢-3H-萘并[2,1-b]吡喃-3-酮

[ 英文名 ]:
Splitomicin

[中文别名 ]:

斯普利特麻一辛

[英文别名 ]:

Splitomicin
1,2-dihydrobenzo[f]chromen-3-one
1,2-Dihydro-3H-benzo[f]chromen-3-one
MFCD03792600
3H-Naphtho[2,1-b]pyran-3-one, 1,2-dihydro-

斯普利特麻一辛生物活性

[ 描述 ]:

Splitomicin (Splitomycin) 是一种选择性的 Sir2p 抑制剂。Splitomicin 抑制 Sir2 蛋白的 NAD+ 依赖性 HDAC 活性。Splitomicin 抑制酵母提取物中 HDAC,IC50 为 60 μM。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> HDAC

信号通路 >> 表观遗传学 >> HDAC

[ 靶点 ]

Sir2p:60 μM (IC50)

[体内研究]

Splitomicin(80 mg/kg,每24小时腹腔注射5天,小鼠)可增强动脉血管壁中的组织因子(TF)活性,并加速光化学损伤模型中颈动脉血栓的形成[2]。动物模型：12-14周龄的C57BL/6小鼠平均体重27g[2]剂量：80mg/kg给药：每24小时腹膜内注射5天结果：与对照相比,小鼠颈动脉TF活性增加。

[参考文献]

[1]. Bedalov A, et al. Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8.

[2]. Breitenstein A, et al. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res. 2011 Feb 1;89(2):464-72.

斯普利特麻一辛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
383.6±17.0 °C at 760 mmHg

[ 熔点 ]:
73-74.5℃

[ 分子式 ]:
C₁₃H₁₀O₂

[ 分子量 ]:
198.217

[ 闪点 ]:
161.2±18.4 °C

[ 精确质量 ]:
198.068085

[ PSA ]:
26.30000

[ LogP ]:
3.03

[ 外观性状 ]:
solid

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.656

[ 储存条件 ]:
2-8°C

斯普利特麻一辛MSDS

斯普利特麻一辛安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2914399090

斯普利特麻一辛合成路线

斯普利特麻一辛上下游产品

斯普利特麻一辛上游产品

斯普利特麻一辛下游产品

斯普利特麻一辛海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

斯普利特麻一辛文献

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis.

Eur. Heart J. 31 , 2301-9, (2010)

Endothelial activation, macrophage infiltration, and foam cell formation are pivotal steps in atherogenesis. Our aim in this study was to analyse the role of SIRT1, a class III deacetylase with import...

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

PLoS ONE 4(6) , e6093, (2009)

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus...

Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.

Cardiovasc. Res. 89 , 464-72, (2011)

The mammalian silent information regulator-two 1 (Sirt1) blunts the noxious effects of cardiovascular risk factors such as type 2 diabetes mellitus and obesity. Nevertheless, the role of Sirt1 in regu...

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